ISSN 1941-5923

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Welcome to the American Journal of Case Reports

Clinical case reports are an invaluable first-hand source of evidence in medicine and a tool most often used in practice to exchange information and generate a more expanded search for evidence. In addition to the “evidence of what happened”, single or multiple cases are an important basis for further and more advanced research on diagnosis,  treatment effectiveness, causes and outcomes of disease. However limited their... read more


Published: 2015-01-31

Disseminated Intravascular Coagulation with Congestive Heart Failure and Left Ventricular Thrombus: A Case Report with Literature Review of 7 Cases

Dmitri Belov, Radmila Lyubarova, Steven Fein, Mikhail Torosoff

(Division of Cardiology, Department of Medicine, Albany Medical Center, Albany, NY, USA)

Am J Case Rep 2015; 16:53-56

DOI: 10.12659/AJCR.892380


Background: Coagulation abnormalities can accompany acute congestive heart failure (CHF). However, disseminated intravascular coagulation (DIC) is rarely documented in such patients. DIC is characterized by generalized excessive activation of coagulation pathways followed by their depletion with secondary activation of anticoagulation and fibrinolysis. Treatment of the cause is an integral part of management of DIC; thus, recognition of the cause is critical.
Case Report: A 55-year-old previously healthy man presented with breathlessness, swelling of both legs, and left leg pain. His physical exam result was consistent with decompensated heart failure. Further testing revealed multiple deep venous thrombi in the upper and lower extremities, arterial occlusion in the left popliteal artery, and an unusual cyst-like left ventricular thrombus. His laboratory evaluation was consistent with severe acute DIC. The patient was managed aggressively with diuretics, transfusions of platelets, and cryoprecipitate and was subsequently anticoagulated. His platelet count and coagulation parameters normalized and coronary angiography did not reveal any obstructive lesions. On day 22, an echocardiogram revealed and MRI confirmed that the intracardiac thrombus had disappeared. He underwent revascularization of the left leg and was successfully discharged from the hospital.
Conclusions: Severe biventricular non-ischemic cardiac dysfunction with intra-cardiac thrombi should be considered in patients presenting with DIC. In addition to anticoagulation, treatment of underlying heart failure is critical in such cases.

Keywords: Disseminated Intravascular Coagulation, Embolism and Thrombosis, Heart Failure, Tricuspid Valve Insufficiency




Published: 2015-01-30

Life-Threatening Neonatal Epidural Hematoma Caused by Precipitous Vaginal Delivery


Justin B. Josephsen, Joanna Kemp, Samer K. Elbabaa, Mohamad Al-Hosni

Am J Case Rep 2015; 16:50-52

DOI: 10.12659/AJCR.892506

Published: 2015-01-28

A Complication of Tracheobronchopathia Osteochondroplastica Presenting as Acute Hypercapnic Respiratory F...


Mauricio Danckers, Roy A. Raad, Ronaldo Zamuco, Aron Pollack, Scott Rickert, Caralee Caplan-Shaw

Am J Case Rep 2015; 16:45-49

DOI: 10.12659/AJCR.892427