Logo American Journal of Case Reports

Call: 1.631.629.4328
Mon-Fri 10 am - 2 pm EST

Contact Us

Logo American Journal of Case Reports Logo American Journal of Case Reports Logo American Journal of Case Reports

02 January 2005 : Original article  Poland

Chronic hepatitis with diffuse steatosis and slight fibrosis related to etretinate therapy

Leonardo Calza, Gabriella Verucchi, Luciano Attard, Roberto Manfredi, Francesco Chiodo

Case Rep Clin Pract Rev 2005; 6:20-23 :: ID: 16402

Abstract

Summary
Background: Etretinate, an aromatique retinoid, has been used to treat severe or treatment-resistant psoriasis, and has been found to cause transient, mild abnormalities of liver function tests in about
one third of patients. Significant liver disease may occur in a few patients, ranging from acute hepatitis to chronic, aggressive hepatitis and cirrhosis.
Case report: A case of chronic hepatitis associated with steatosis and fibrosis in a 39-year-old male patient treated with etretinate for severe palmoplantar psoriasis is reported. Results of periodical liver
function tests were still normal 4 and 8 weeks after initiation of etretinate therapy, but became abnormal 12 weeks later, when asthenia was referred and liver enzyme levels were found to
be elevated. The liver enzyme levels gradually decrease after therapy with retinoid was stopped, but these biochemical abnormalities were still evident 5 years later. The liver biopsy showed small inflammatory cell infiltrates, in addition to initial, slight fibrosis, steatosis, and
ductular proliferation, and ultrastructural study of biopsy specimens demonstrated diffuse abnormalities, consistent with a drug-related, chronic liver damage.
Conclusions: Etretinate therapy may lead to a wide spectrum of hepatotoxic reactions, ranging from nonspecific reactive hepatitis to cirrhosis, and requires a close monitoring of liver function during
the first 6 months.

Keywords: etretinate, aromatic retinoid, Psoriasis, chronic hepatitis, steatosis, Fibrosis

Add Comment 0 Comments

22

In Press

12 Feb 2024 : Case report  Germany

Diagnostic Challenges and Imaging Considerations for Intraparotid Facial Nerve Schwannoma: A Case Report an...

Am J Case Rep In Press; DOI: 10.12659/AJCR.942870  

0:00

12 Feb 2024 : Case report  USA

Erdheim-Chester Disease Occult on Radiographs and CT but Visible on MRI and PET

Am J Case Rep In Press; DOI: 10.12659/AJCR.941169  

0:00

12 Feb 2024 : Case report  USA

Surgical Treatment of Spontaneous Superficial Temporal Artery Arteriovenous Malformation: A Case Report

Am J Case Rep In Press; DOI: 10.12659/AJCR.942839  

13 Feb 2024 : Case report  Bahrain

Warfarin Woes: A Rare Case of Hemoperitoneum with Intramural Small Bowel Hematoma

Am J Case Rep In Press; DOI: 10.12659/AJCR.943519  

Most Viewed Current Articles

10 Jan 2022 : Case report  Germany

A Report on the First 7 Sequential Patients Treated Within the C-Reactive Protein Apheresis in COVID (CACOV...

DOI :10.12659/AJCR.935263

Am J Case Rep 2022; 23:e935263

19 Jul 2022 : Case report  Saudi Arabia

Atlantoaxial Subluxation Secondary to SARS-CoV-2 Infection: A Rare Orthopedic Complication from COVID-19

DOI :10.12659/AJCR.936128

Am J Case Rep 2022; 23:e936128

05 Mar 2022 : Case report  Brazil

Acute Limb Ischemia After Self-Injection of Crushed Morphine Tablets into the Radial Artery: Role of Infrar...

DOI :10.12659/AJCR.935336

Am J Case Rep 2022; 23:e935336

02 Apr 2022 : Case report  Saudi Arabia

Infective Endocarditis Caused by Pseudomonas luteola in a Pediatric Patient. A Case Report and Review of Li...

DOI :10.12659/AJCR.935743

Am J Case Rep 2022; 23:e935743

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923