Logo American Journal of Case Reports

Call: 1.631.629.4328
Mon-Fri 10 am - 2 pm EST

Contact Us

Logo American Journal of Case Reports Logo American Journal of Case Reports Logo American Journal of Case Reports

01 April 2004

Treatment with HMG-CoA reductase inhibitors and fibrates results in a long-term reduction of markers of disease severity in PBC

Makoto Nakamuta, Kazuhiro Kotoh, Munechika Enjoji, Hajime Nawata

Case Rep Clin Pract Rev 2004; 5(null):537-541 :: ID: 428992

Abstract

Background: 3-hydroxy-3-methylglutaryl coenzyme A-reductase inhibitor as well as fibrate, lipid-lowering drugs, recently has been reported to reduce disease markers of primary biliary cirrhosis (PBC). Case Report: We report the long-term observation of a case of PBC treated sequentially with several lipidlowering drugs and the effects of these drugs on the liver function tests. A 39-year-old female was diagnosed as PBC because of liver dysfunction accompanying high levels of immunoglobulin M (IgM), positive antimitochondrial antibody (AMA), and histological findings as stage II of PBC. She was also diagnosed as familial hypercholesteremia (IIa) because of her family history. She was treated with ursodeoxycholic acid (UDCA), which led to a transient improvement in liver function tests. Consequently, she was sequentially given several lipid-lowering drugs, probucol, bezafibrate, pravastatin and atorvastatin in addition to UDCA because of high levels of cholesterol. Bezafibrate, pravastatin, and atrovastatin, but not probucol, reduce disease markers of PBC. Particularly, long-term treatment with atorvastatin for more than 2.5 years led to continuously improving most significantly, not only the colesterol levels, but also liver function tests including IgM and AMA, compared to the other lipid-lowering drugs used throughout the clinical course. There were no side effects throughout the treatment. Conclusions: Our case indicates that statins, as well as fibrates, could ameliorate PBC in the long-term without side effects, suggesting that statins may be a first-line treatment for PBC particularly in patients with hypercholesteremia.

Keywords: PBC, HMG-CoA reductase inhibitors, Statin, fibrates, Probucol, Multiple drug-resistant gene (MDR), Phospholipid, Ursodeoxycholic acid (UDCA)

Add Comment 0 Comments

25

In Press

12 Feb 2024 : Case report  Germany

Diagnostic Challenges and Imaging Considerations for Intraparotid Facial Nerve Schwannoma: A Case Report an...

Am J Case Rep In Press; DOI: 10.12659/AJCR.942870  

0:00

12 Feb 2024 : Case report  USA

Erdheim-Chester Disease Occult on Radiographs and CT but Visible on MRI and PET

Am J Case Rep In Press; DOI: 10.12659/AJCR.941169  

0:00

12 Feb 2024 : Case report  USA

Surgical Treatment of Spontaneous Superficial Temporal Artery Arteriovenous Malformation: A Case Report

Am J Case Rep In Press; DOI: 10.12659/AJCR.942839  

13 Feb 2024 : Case report  Bahrain

Warfarin Woes: A Rare Case of Hemoperitoneum with Intramural Small Bowel Hematoma

Am J Case Rep In Press; DOI: 10.12659/AJCR.943519  

Most Viewed Current Articles

10 Jan 2022 : Case report  Germany

A Report on the First 7 Sequential Patients Treated Within the C-Reactive Protein Apheresis in COVID (CACOV...

DOI :10.12659/AJCR.935263

Am J Case Rep 2022; 23:e935263

19 Jul 2022 : Case report  Saudi Arabia

Atlantoaxial Subluxation Secondary to SARS-CoV-2 Infection: A Rare Orthopedic Complication from COVID-19

DOI :10.12659/AJCR.936128

Am J Case Rep 2022; 23:e936128

05 Mar 2022 : Case report  Brazil

Acute Limb Ischemia After Self-Injection of Crushed Morphine Tablets into the Radial Artery: Role of Infrar...

DOI :10.12659/AJCR.935336

Am J Case Rep 2022; 23:e935336

02 Apr 2022 : Case report  Saudi Arabia

Infective Endocarditis Caused by Pseudomonas luteola in a Pediatric Patient. A Case Report and Review of Li...

DOI :10.12659/AJCR.935743

Am J Case Rep 2022; 23:e935743

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923