07 October 2008
Malignant pleural mesothelioma with spinal fracture – a case report
Pregash Ellapparadja, Pradeep Madhavan, Susan SlaterAm J Case Rep 2008; 9:408-410 :: ID: 869421
Abstract
Background: Malignant mesothelioma is an aggressive tumor of serosal surfaces, such as the pleura and the peritoneum. Local invasion is common involving the adjacent organs. Distant metastasis is rare.
Case Report: We present an interesting case report of a 60-year-old lady with malignant pleural mesothelioma with vertebral collapse, which initially thought to be a metastasis turned out to be vertebral infarction due to compromise in blood supply to the vertebra as a result of contiguous spread of the mesothelioma. This lady presented with low back ache, nontraumatic in origin without neurological symptoms. CT and MR scan revealed significant changes in T12 vertebra with vertebral collapse. Surgical intervention was necessary to obtain pain relief and to get bone sample for biopsy to confirm diagnosis. Histopathological examination of bone specimens revealed samples of bone containing normal haematopoietic tissue together with fragments of partly degenerative necrotic tissue. No morphologically or immunohistochemically viable tumour was identified.
Conclusions: Analysing the various possible causes for vertebral collapse from literature, CT/MRI scan and biopsy report, we identified that the pleural mesothelioma had spread in contiguity, encircled the spine near the thoraco-lumbar junction and interfered with the vascular supply of the vertebral body leading to collapse of the T12 vertebra.
Keywords: malignant mesothelioma, Back Pain, vertebral collapse, spinal stabilisation
In Press
14 Mar 2024 : Case report
Simultaneous Occurrence of Collagen Type III Glomerulopathy and Immunoglobulin A Nephropathy: A Rare Case R...Am J Case Rep In Press; DOI: 10.12659/AJCR.942770
16 Mar 2024 : Case report
Castleman Disease Presenting in the Neck: A Report of 3 Cases and a Literature ReviewAm J Case Rep In Press; DOI: 10.12659/AJCR.943214
16 Mar 2024 : Case report
Early Diagnosis and Successful Empirical Treatment of L1-L2 Spondylodiscitis in a 21-Month-Old Girl: A Case...Am J Case Rep In Press; DOI: 10.12659/AJCR.943010
16 Mar 2024 : Case report
A Rare Autochthonous Case of Hepatic Hydatid Cyst in the Non-Endemic Region of TaiwanAm J Case Rep In Press; DOI: 10.12659/AJCR.943687
Most Viewed Current Articles
07 Mar 2024 : Case report
Neurocysticercosis Presenting as Migraine in the United StatesDOI :10.12659/AJCR.943133
Am J Case Rep 2024; 25:e943133
10 Jan 2022 : Case report
A Report on the First 7 Sequential Patients Treated Within the C-Reactive Protein Apheresis in COVID (CACOV...DOI :10.12659/AJCR.935263
Am J Case Rep 2022; 23:e935263
19 Jul 2022 : Case report
Atlantoaxial Subluxation Secondary to SARS-CoV-2 Infection: A Rare Orthopedic Complication from COVID-19DOI :10.12659/AJCR.936128
Am J Case Rep 2022; 23:e936128
23 Feb 2022 : Case report
Penile Necrosis Associated with Local Intravenous Injection of CocaineDOI :10.12659/AJCR.935250
Am J Case Rep 2022; 23:e935250