Logo American Journal of Case Reports

Call: 1.631.629.4328
Mon-Fri 10 am - 2 pm EST

Contact Us

Logo American Journal of Case Reports Logo American Journal of Case Reports Logo American Journal of Case Reports

30 August 2010

Prophylactic femoral intramedullary nailing for impending fracture associated with bisphosphate use

Paul T. Hak, Mel W. Jones

Am J Case Rep 2010; 11:155-158 :: ID: 881139

Abstract

Background: The use of bisphosphate therapy in the primary and secondary prevention of low energy fragility fractures associated with osteoporosis has been well documented and shown to be efficacious. Recently however a new clinical entity of femoral fractures associated with abnormal bone remodeling in the patient population taking long term bisphosphonates seems to have become apparent.
Case Report: We describe an 85-year-old female presenting with a low velocity femoral fracture with features associated with bisphosphonate use and a history of contralateral thigh pain. Characteristic radiographic changes associated with bisphosphonate use and the development of abnormal bone remodeling has been documented. Following investigation an impending bisphosphate fragility fracture was found and we describe, to our knowledge, the first prophylactic intramedullary nailing of an impending femoral shaft fracture associated with bisphosphonate use.
Conclusions: The exact biochemical mechanisms of abnormal bone remodeling in patients taking long term bisphosphonates is not well understood, and further investigation is needed as evidence of bisphosphonate associated fragility fractures mounts. We describe prophylactic surgical treatment for impending fracture and highlight the need for patient information with regards the potential risk of fracture and the clinical symptoms that would necessitate further consultation, investigation and treatment for impending fracture.

Keywords: bisphosphonates, low-energy fracture, Femoral Fractures

Add Comment 0 Comments

In Press

12 Feb 2024 : Case report  Germany

Diagnostic Challenges and Imaging Considerations for Intraparotid Facial Nerve Schwannoma: A Case Report an...

Am J Case Rep In Press; DOI: 10.12659/AJCR.942870  

0:00

12 Feb 2024 : Case report  USA

Erdheim-Chester Disease Occult on Radiographs and CT but Visible on MRI and PET

Am J Case Rep In Press; DOI: 10.12659/AJCR.941169  

0:00

12 Feb 2024 : Case report  USA

Surgical Treatment of Spontaneous Superficial Temporal Artery Arteriovenous Malformation: A Case Report

Am J Case Rep In Press; DOI: 10.12659/AJCR.942839  

13 Feb 2024 : Case report  Bahrain

Warfarin Woes: A Rare Case of Hemoperitoneum with Intramural Small Bowel Hematoma

Am J Case Rep In Press; DOI: 10.12659/AJCR.943519  

Most Viewed Current Articles

10 Jan 2022 : Case report  Germany

A Report on the First 7 Sequential Patients Treated Within the C-Reactive Protein Apheresis in COVID (CACOV...

DOI :10.12659/AJCR.935263

Am J Case Rep 2022; 23:e935263

19 Jul 2022 : Case report  Saudi Arabia

Atlantoaxial Subluxation Secondary to SARS-CoV-2 Infection: A Rare Orthopedic Complication from COVID-19

DOI :10.12659/AJCR.936128

Am J Case Rep 2022; 23:e936128

05 Mar 2022 : Case report  Brazil

Acute Limb Ischemia After Self-Injection of Crushed Morphine Tablets into the Radial Artery: Role of Infrar...

DOI :10.12659/AJCR.935336

Am J Case Rep 2022; 23:e935336

02 Apr 2022 : Case report  Saudi Arabia

Infective Endocarditis Caused by Pseudomonas luteola in a Pediatric Patient. A Case Report and Review of Li...

DOI :10.12659/AJCR.935743

Am J Case Rep 2022; 23:e935743

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923