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Nine-year follow-up of local implantation of autologous skeletal myoblasts in a patient with coronary heart disease

Dingguo Zhang, Liansheng Wang, Fumin Zhang, Chunjian Li, Tiebing Zhu, Kejiang Cao, Wenzhu Ma, Zhijian Yang

Am J Case Rep 2013; 14:139-142

DOI: 10.12659/AJCR.883903

Published: 2013-05-06

Background: Cell transplantation has been viewed as a promising strategy for end-stage heart failure, but long-term follow-up results are lacking.
Case Report: In December 2002 we began transplanting autologous skeletal myoblasts in one patient because of serious coronary heart disease. Here, we present the 9-year follow-up results of this patient. No ventricular tachyarrhythmias were detected after treatment. The patient had another myocardial infarction in April 2012 and was treated successful with PCI.
Conclusions: Autologous skeletal myoblast transplantation with bypass surgery is associated with improvement in cardiac function and lack of adverse effects in long-term follow-up, making it a promising therapy for patients with heart failure.

Keywords: skeletal myoblast , cellular transplantation, ischemic heart disease, Heart Failure - drug therapy