ISSN 1941-5923

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Methemoglobinemia in a Pediatric Oncology Patient Receiving Sulfamethoxazole/Trimethoprim Prophylaxis

Timothy G. Carroll, Megan G. Carroll

(Department of Pediatrics, Section of Critical Care, University of Oklahoma Health Science Center, Oklahoma City, OK, USA)

Am J Case Rep 2016; 17:499-502

DOI: 10.12659/AJCR.897820

Published: 2016-07-18


BACKGROUND: Methemoglobinemia due to the administration of sulfamethoxazole/trimethoprim has been documented in a series of case reports. However, all of these reports are on adult patients, and all patients received at least daily administration of sulfamethoxazole/trimethoprim for the treatment of active or suspected infection.
CASE REPORT: Herein we report the development of methemoglobinemia in a pediatric patient receiving sulfamethoxazole/trimethoprim three times weekly for the prophylaxis of opportunistic infections.
CONCLUSIONS: The clinician should always consider sulfamethoxazole/trimethoprim, even when administered for opportunistic infection prophylaxis at reduced doses and intervals, as a possible cause of methemoglobinemia.

Keywords: Leukemia, Myelomonocytic, Juvenile - complications, Infant, Humans, Male, Methemoglobinemia - chemically induced, Opportunistic Infections - prevention & control, Trimethoprim, Sulfamethoxazole Drug Combination - therapeutic use



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