01 February 2006
Integrin and Interleukin-1 Receptor Type I Expression in Pancreatic Tissue from a Patient with Chronic Pancreatitis Complicated with Pancreas Divisum: Report of a Case
Hirozumi Sawai, Hitoshi Funahashi, Yuji Okada, Yoichi Matsuo, Hiroki Takahashi, Hiromitsu Takeyama, Tadao ManabeCase Rep Clin Pract Rev 2006; 7:44-47 :: ID: 446795
Abstract
Background: Any link between chronic pancreatitis and pancreatic cancer could reflect the malignant potential of a chronic inflammatory process. In this case report, we investigated the occurrence of a possible malignancy within the chronic pancreatitis tissue and present here a clinicopathological and
immunohistochemical features of a case of chronic pancreatitis with pancreas divisum.
Case Report: A 39-year-old Japanese man was admitted to our hospital, presenting with severe abdominal and
back pain due to chronic pancreatitis. Endoscopic retrograde pancreatography demonstrated the pancreas divisum, dilatation of the main pancreatic duct, and a cystic lesion in the accessory pancreatic duct of Santorini. Computed tomography demonstrated pancreatolithiasis in the whole pancreas. Under diagnosis of chronic pancreatitis with pancreas divisum, laparotomy was performed. Then a pylorus-preserving pancreaticoduodenectomy and side-to-side
pancreatojejunostomy were performed on suspicion of malignant disease in the pancreatic head. Immunohistochemical examination revealed the absence of p53 protein and presence of α[sub]6[/sub] integrin subunit and interleukin-1 receptor type I.
Conclusions: Our results indicated the possibility of malignancy in conjunction with chronic pancreatitis and pancreas divisum in this patient.
Keywords: chronic pancreatitis, Integrins, Pancreas divisum
4
In Press
12 Feb 2024 : Case report
Diagnostic Challenges and Imaging Considerations for Intraparotid Facial Nerve Schwannoma: A Case Report an...Am J Case Rep In Press; DOI: 10.12659/AJCR.942870
12 Feb 2024 : Case report
Erdheim-Chester Disease Occult on Radiographs and CT but Visible on MRI and PETAm J Case Rep In Press; DOI: 10.12659/AJCR.941169
12 Feb 2024 : Case report
Surgical Treatment of Spontaneous Superficial Temporal Artery Arteriovenous Malformation: A Case ReportAm J Case Rep In Press; DOI: 10.12659/AJCR.942839
13 Feb 2024 : Case report
Warfarin Woes: A Rare Case of Hemoperitoneum with Intramural Small Bowel HematomaAm J Case Rep In Press; DOI: 10.12659/AJCR.943519
Most Viewed Current Articles
10 Jan 2022 : Case report
A Report on the First 7 Sequential Patients Treated Within the C-Reactive Protein Apheresis in COVID (CACOV...DOI :10.12659/AJCR.935263
Am J Case Rep 2022; 23:e935263
19 Jul 2022 : Case report
Atlantoaxial Subluxation Secondary to SARS-CoV-2 Infection: A Rare Orthopedic Complication from COVID-19DOI :10.12659/AJCR.936128
Am J Case Rep 2022; 23:e936128
05 Mar 2022 : Case report
Acute Limb Ischemia After Self-Injection of Crushed Morphine Tablets into the Radial Artery: Role of Infrar...DOI :10.12659/AJCR.935336
Am J Case Rep 2022; 23:e935336
02 Apr 2022 : Case report
Infective Endocarditis Caused by Pseudomonas luteola in a Pediatric Patient. A Case Report and Review of Li...DOI :10.12659/AJCR.935743
Am J Case Rep 2022; 23:e935743