RCAS1-expressing macrophages increase during the recovery phase of inflammatory liver diseases
Munechika Enjoji, Kazuhiro Kotoh, Masaki Kato, Makoto NakamutaCase Rep Clin Pract Rev 2007; 8:165-168 :: ID: 488669
Abstract
Background: In our previous histological analyses, RCAS1-positive macrophages were not detected on biopsy samples from patients with inflammatory liver diseases, if their inflammation was not severe; that is, serum alanine aminotransferase (ALT) levels of less than 200 IU/L. In contrast, Fas ligand (FasL)-positive mononuclear cells including macrophages were detected
in most of the samples regardless of serum ALT levels.
Case Report: We immunohistochemically assessed the expression of RCAS1, FasL, and a specific marker for macrophages (LN-5) in liver biopsy samples from 2 patients, a 51-year-old woman with acute on chronic hepatitis B and a 52-year-old man with autoimmune hepatitis, in whom severe inflammation was present before starting medical treatment. FasL- and/or RCAS1-positive macrophages were infiltrated mainly at the areas of hepatocytic damage.
FasL-positive macrophages increased in proportion to serum transaminase levels. In contrast, few RCAS1-positive macrophages were detected near the peak of inflammation but their numbers increased during the recovery phase.
Conclusions: The number of FasL- and RCAS1-positive macrophages showed positive and negative correlation with the degree of inflammation, respectively. Both FasL and RCAS1 are apoptosis-inducing molecules, however, target cells of each may be different in hepatitis.
Keywords: Hepatitis B
23
In Press
14 Mar 2024 : Case report
Eosinophilic Pleural Effusion Secondary to Trichinella spiralis Infection in a Patient with Systemic Sclero...Am J Case Rep In Press; DOI: 10.12659/AJCR.943420
14 Mar 2024 : Case report
Laparoscopic Sleeve Gastrectomy with Staple-Line Oversewing in a Patient with Factor XI Deficiency: A Case ...Am J Case Rep In Press; DOI: 10.12659/AJCR.942824
14 Mar 2024 : Case report
Pathogenic Potential of a PCK1 Gene Variant in Cytosolic PEPCK Deficiency: A Compelling Case StudyAm J Case Rep In Press; DOI: 10.12659/AJCR.943118
14 Mar 2024 : Case report
Management of Nontraumatic Spontaneous Renal Hemorrhage (Wünderlich Syndrome) through Robotic-Assisted Lapa...Am J Case Rep In Press; DOI: 10.12659/AJCR.942826
Most Viewed Current Articles
07 Mar 2024 : Case report
Neurocysticercosis Presenting as Migraine in the United StatesDOI :10.12659/AJCR.943133
Am J Case Rep 2024; 25:e943133
10 Jan 2022 : Case report
A Report on the First 7 Sequential Patients Treated Within the C-Reactive Protein Apheresis in COVID (CACOV...DOI :10.12659/AJCR.935263
Am J Case Rep 2022; 23:e935263
19 Jul 2022 : Case report
Atlantoaxial Subluxation Secondary to SARS-CoV-2 Infection: A Rare Orthopedic Complication from COVID-19DOI :10.12659/AJCR.936128
Am J Case Rep 2022; 23:e936128
23 Feb 2022 : Case report
Penile Necrosis Associated with Local Intravenous Injection of CocaineDOI :10.12659/AJCR.935250
Am J Case Rep 2022; 23:e935250