ISSN 1941-5923

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Welcome to the American Journal of Case Reports

Clinical case reports are an invaluable first-hand source of evidence in medicine and a tool most often used in practice to exchange information and generate a more expanded search for evidence. In addition to the “evidence of what happened”, single or multiple cases are an important basis for further and more advanced research on diagnosis,  treatment effectiveness, causes and outcomes of disease. However limited their... read more


Published: 2015-07-03

Impressive Response to Dose-Dense Chemotherapy in a Patient with NUT Midline Carcinoma

Michela Maur, Angela Toss, Massimo Dominici, Antonio Frassoldati, Paolo Corradini, Antonio Maiorana, Annalisa Fontana, Pierfranco Conte

(Division of Oncology, Department of Medical and Surgical Sciences for Children and Adults, University Hospital of Modena and Reggio Emilia, Modena, Italy)

Am J Case Rep 2015; 16:424-429

DOI: 10.12659/AJCR.893879


BACKGROUND: NUT midline carcinoma (NMC) is a rare, highly lethal malignancy that results from a chromosome translocation and mostly arises in the midline organs. To date, no treatment has been established. Most patients receive combinations of chemotherapy regimens and radiation, and occasionally subsequent resection; nevertheless, patients have an average survival hardly exceeding 7 months.
CASE REPORT: A 21-year-old patient was admitted to our division with a large mediastinal mass with lung nodules, multiple vertebral metastases, and massive nodal involvement. In a few days, the patient developed a superior vena cava syndrome and an acute respiratory failure. Due to the rapid course of the disease, based on preliminary histology of poorly differentiated carcinoma, a dose-dense biweekly chemotherapy with paclitaxel, ifosfamide, and cisplatin was started. In the meantime, the diagnosis of NMC was confirmed. A surprising clinical benefit was obtained after the first cycle of chemotherapy, and after 6 cycles a PET-CT scan showed a very good response. At this point, radiotherapy was started but the disease progressed outside of the radiation field. The patient entered into a compassionate use protocol with Romidepsin, but a PET/CT scan after the first course showed disease progression with peritoneal and retroperitoneal carcinosis. A treatment with Pemetrexed was then started but the patient eventually died with rapid progressive disease.
CONCLUSIONS: Our case history adds some interesting findings to available knowledge: NMC can be chemosensitive and radiosensitive. This opens the possibility to study more aggressive treatments, including high-dos... read more

Keywords: Antineoplastic Agents, Carcinoma, Mediastinal Neoplasms, Translocation, Genetic




Published: 2015-07-02

Bubbles in the Pericardium


Aditya Saini, Brijesh Patel

Am J Case Rep 2015; 16:420-423

DOI: 10.12659/AJCR.893877

Published: 2015-07-01

Ameloblastic Carcinoma


Dakshika Abeydeera Gunaratne, Hedley G. Coleman, Lydia Lim, Gary J. Morgan

Am J Case Rep 2015; 16:415-419

DOI: 10.12659/AJCR.893918