ISSN 1941-5923

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Welcome to the American Journal of Case Reports

Clinical case reports are an invaluable first-hand source of evidence in medicine and a tool most often used in practice to exchange information and generate a more expanded search for evidence. In addition to the “evidence of what happened”, single or multiple cases are an important basis for further and more advanced research on diagnosis,  treatment effectiveness, causes and outcomes of disease. However limited their... read more


Published: 2014-09-27

Intrahepatic Splenosis in a Chronic Hepatitis C Patient with no History of Splenic Trauma Mimicking Hepatocellular Carcinoma

Naoya Sato, Tsuyoshi Abe, Nobuyasu Suzuki, Mitsuru Waragai, Yasushi Teranishi, Yoshinao Takano, Atai Sato, Ayaka Azami, Mitsukazu Gotoh

(Department of Surgery, Southern Tohoku Research Institute for Neuroscience, Koriyama, Japan)

Am J Case Rep 2014; 15:416-420

DOI: 10.12659/AJCR.890999


Background: Intrahepatic splenosis (IHS) is the autotransplantation of splenic tissue that mostly develops after abdominal injury and is often misdiagnosed as hepatocellular carcinoma (HCC) because of similarities in radiological features. We had an opportunity to treat an extremely rare case of intrahepatic splenosis, which were found in a patient without any history of splenic injury. To the best of our knowledge, this is the first such case report in the world.
Case Report: A 58-year-old man with chronic hepatitis C was referred to our hospital for further examination of liver function abnormality. Abdominal ultrasonography incidentally revealed a low echoic tumor in the posterior segment of the liver, with high echoic capsule, which is possibly different from tumor capsule of HCC, known as halo. Abdominal contrast-enhanced computed tomography and gadoxetic acid-enhanced magnetic resonance imaging showed that the tumor had an inhomogeneous enhancement in the arterial phase and diminished enhancement in the equilibrium phase, diagnosed as HCC. The patient underwent right lateral segmentectomy of the liver, and histopathological study confirmed a diagnosis of intrahepatic splenosis.
Conclusions: This case presents a new understanding of IHS in a patient without any splenic injury. We also focused on the differences in echo patterns of the tumor capsule between HCC and IHS, which can be used to efficiently diagnose IHS.

Keywords: Hepatitis, Chronic, Liver Neoplasms, Splenosis




Published: 2014-09-25

Acute Cranial Neuropathies Heralding Neurosyphilis in Human Immunodeficiency Virus-Infected Patient


Saeed Alqahtani

Am J Case Rep 2014; 15:411-415

DOI: 10.12659/AJCR.892292

Published: 2014-09-22

Burkitt Lymphoma with Initial Clinical Presentation due to Infiltration of the Central Nervous System and...


Gustavo Bittencourt Camilo, Dequitier Carvalho Machado, Celso Estevão de Oliveira, Letícia da Silva Lacerda, Romulo Varella de Oliveira, Monique de França Silva, Agnaldo José Lopes

Am J Case Rep 2014; 15:404-410

DOI: 10.12659/AJCR.891224