ISSN 1941-5923



American Journal of Case Reports have been selected for the ESCI - Emerging Sources Citation Index (Thomson Reuters, Web of Science, ISI), launching in November of 2015 as a new edition of the Web of Science.

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Published: 2015-11-30

Oral Spindle Cell Lipoma in a Rare Location: A Differential Diagnosis

Filipe Jaeger, Hermínia Marques Capistrano, Wagner Henriques de Castro, Patrícia Carlos Caldeira, Maria Auxiliadora Vieira do Carmo, Ricardo Alves de Mesquita, Maria Cássia Ferreira de Aguiar

(Department of Oral Pathology and Surgery, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil)

Am J Case Rep 2015; 16:844-848

DOI: 10.12659/AJCR.895474

BACKGROUND: Spindle cell lipoma (SCL) is an uncommon and histologically distinct variant of lipoma. It usually occurs as a solitary, subcutaneous, and well-circumscribed lesion in the posterior neck, shoulders, and back of older men. SCL of the oral cavity is rare. We present the clinical-pathologic features of the third case of SCL located on the hard palate and discuss the histological differential diagnosis with other fusiform neoplasms.
CASE REPORT: A 56-year-old man was evaluated for an asymptomatic swelling on the right side of the hard palate. The intraoral examination showed a 25×20 mm sessile and circumscribed tumor, underlying an apparently healthy mucosa of normal color. The lesion revealed a floating consistency during palpation. Excisional biopsy was carried out based on a clinical diagnosis of lipoma or a benign minor salivary gland tumor. The histopathology demonstrated a well-circumscribed but unencapsulated proliferation of bland spindle cells admixed with mature adipocytes in a collagenous/myxoid stroma. The spindle cells were uniform, exhibiting elongated nuclei and narrow cytoplasmic processes without atypia. They were positive to CD34 and negative to factor VIII, alpha-smooth muscle actin, S100, cytokeratin, and actin. Mitotic activity was low, as confirmed by Ki-67 immunostaining. No lipoblastic activity was found. The diagnosis of SCL was therefore established.
CONCLUSIONS: Oral spindle cell lipoma is a rare benign lipomatous tumor. The histologic picture shows a range of variations and the observation of morphological features is important to distinguish this lesion from other fusiform tumors. Immunohistochemistry should be he... read more

Keywords: Diagnosis, Differential, Immunohistochemistry, Lipoma

Published: 2015-11-28

Rare but Lethal Hepatopathy-Sickle Cell Intrahepatic Cholestasis and Management Strategies

Aamir Malik, Chandni Merchant, Mana Rao, Rosemary P. Fiore

Am J Case Rep 2015; 16:840-843

DOI: 10.12659/AJCR.895218

Published: 2015-11-26

Colon Adenocarcinoma Associated with Synchronous Extramural Gastrointestinal Stromal Tumor (GIST) of the ...

Paschalis Gavriilidis, Anastasia Nikolaidou

Am J Case Rep 2015; 16:837-839

DOI: 10.12659/AJCR.894845