ISSN 1941-5923

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Welcome to the American Journal of Case Reports

Clinical case reports are an invaluable first-hand source of evidence in medicine and a tool most often used in practice to exchange information and generate a more expanded search for evidence. In addition to the “evidence of what happened”, single or multiple cases are an important basis for further and more advanced research on diagnosis,  treatment effectiveness, causes and outcomes of disease. However limited their... read more


Published: 2014-11-25

A Rare Case of β-hCG Production by a Solitary Fibrous Tumor of the Pleura

Irfanali Rajabali Kugasia, Mohammad Alkayem, Jigar B. Patel

(Department of Internal Medicine, Lincoln Medical and Mental Health Center, Bronx, USA)

Am J Case Rep 2014; 15:518-522

DOI: 10.12659/AJCR.891171


Background: Solitary fibrous tumors are rare tumors of mesenchymal origins, most commonly seen arising from the pleural lining of the lungs. These are generally benign tumors, which in rare cases have been identified to be associated with multiple para-neoplastic syndromes.
Case Report: This is a case of a solitary fibrous tumor of the pleura in a 49 year old female which was found to be associated with elevated levels of serum beta human chorionic gonadotropin β-hCG). Due to the lack of plausible causes for elevated β-hCG in the patient, immune-histochemical staining of the tumor specimen for β-hCG was obtained. This confirmed the patient’s solitary fibrous tumor as the source of the β-hCG. The patient was also found to have a possible paraneoplastic syndrome with irregular menstruation and hot flushes from the secreted β-hCG.
Conclusions: This is the first reported case of solitary fibrous tumors of the pleura producing {b-hCG. Multiple types of lung tumors have been associated with production of β-subunit of human chorionic gonadotropin. Production of β-hCG by these tumors has been associated with a poor prognosis. In this case, we find an aggressive form of solitary fibrous tumor associated with production of β-hCG and associated paraneoplastic syndrome secondary to the β-hCG. Further study is required to identify the frequency of this phenomenon and the implications of β-hCG production in the prognosis of the solitary fibrous tumors.

Keywords: Chorionic Gonadotropin, beta Subunit, Human, Paraneoplastic Syndromes, Solitary Fibrous Tumor, Pleural




Published: 2014-11-23

Spontaneous Hemarthrosis Following Fibrinolytic Therapy for Acute Myocardial Infarction: A Case Report an...


Mahmoud M. Ramadan, Iqbal S. Khan, Ousama Mahdi

Am J Case Rep 2014; 15:514-517

DOI: 10.12659/AJCR.892138

Published: 2014-11-21

Resolution of an Acute Aortic Syndrome with Aortic Valve Insufficiency Post-PCI


Pedro G.M. de Barros e Silva, Thiago Aquino, Marcos V. Resende, Ivo Richter, Cecilia M. Barros, Vanessa G. Andrioli, Antonio C. Baruzzi, Caio C.J. Medeiros, Valter Furlan

Am J Case Rep 2014; 15:508-513

DOI: 10.12659/AJCR.891301