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American Journal of Case Reports is indexed in ESCI - Emerging Sources Citation Index ( Clarivate, formerly Thomson-Reuters ), as a part of the Web of Science.

American Journal of Case Reports is an Open Access journal which means that all content is freely available without charge to the user or his/her... read more


Published: 2018-12-18

Murine Typhus: A Life-Threatening Presentation of a Case in Galveston, Texas

Christopher Perez, Diaa Hamouda, Bernard Karnath

(Department of Internal Medicine, University of Texas Medical Branch (UTMB), Galveston, USA)

Am J Case Rep 2018; 19:1503-1506

DOI: 10.12659/AJCR.909369


BACKGROUND: Murine typhus is a rare bacterial infection caused by Rickettsia typhi, which is transmitted from rodents to humans through the infected Xenopsylla cheopis flea. The disease presentation is often non-specific, leading to unnecessary tests, and a delay in diagnosis and treatment.
CASE REPORT: A report is presented of a 22-year-old, previously healthy man, who presented with several symptoms and signs that increased in severity, requiring admission to the medical intensive care unit (MICU). After an extensive bacterial and viral laboratory workup, IgM and IgG titers confirmed the diagnosis of murine typhus due to infection by Rickettsia typhi. The patient was treated with doxycycline, which resulted in significant clinical improvement.
CONCLUSIONS: Murine typhus can present with a characteristic triad of fever, headache, and rash but also with other symptoms and signs and can vary in severity. Given its increasing prevalence in coastal cities, awareness of this infection and early diagnosis and treatment with doxycycline can reduce patient morbidity.

Keywords: Bacterial Infections, doxycycline, Rickettsia typhi, Xenopsylla



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