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13 July 2020: Articles

Desmoplastic Small Round Cell Tumor of Pancreatic Origin in a Young Child: A Case Report and Review of Literature

Challenging differential diagnosis, Management of emergency care, Patient complains / malpractice, Rare disease, Adverse events of drug therapy, Clinical situation which can not be reproduced for ethical reasons

Daniyah Saleh A , Sahar Al-Maghrabi A , Haneen Al-Maghrabi A , Jaudah Al-Maghrabi A*

DOI: 10.12659/AJCR.922762

Am J Case Rep 2020; 21:e922762

Figure 1. Radiology and histopathology (hematoxylin and eosin stain [H&E]) examination of the mass. (A) Abdominal computed tomography (CT) scan with contrast. The axial view depicts a large left flank abdominal tumor (15×10.1×6.5 cm; red star) with extensive retroperitoneal and midline extension with distorted pancreatic tissue and significant vascular encasement. (B) (×4; H&E) Sharp demarcated nests formed of undifferentiated small round blue cells surrounded by dense desmoplastic stromal reaction are embedded within the pancreatic parenchyma. (C) (×10; H&E) Nuclear features of DSRCT are primitive-appearing uniform nuclei that exhibit increased nuclear to stromal ratio, dense chromatin, inconspicuous nucleoli, and scant to clear cytoplasm. (D) (×10) The majority of the tumor cells are expressing desmin in a characteristic perinuclear dot-like pattern (yellow arrows). (E) (×10) DSRCT displays strong membranous expression for CD56. (F) (×4) Immunohistochemical staining of DSRCT for neuron-specific enolase indicates that most of the tumor cells were positive for this marker in the cytoplasmic staining pattern.

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923