25 August 2020: Articles
Rifampicin-Induced Pneumonitis Mimicking Severe COVID-19 Pneumonia Infection
Challenging differential diagnosis, Unusual or unexpected effect of treatment, Unexpected drug reaction, Rare disease
Fateen Ata A* , Mousa Shaher Mousa Hussein D , Ahmad Y. Mismar E , Rohit Sharma E , Issam A. M. Bozom E , Zeinab Alsiddig Ali Ibrahim E , Wanis H. Ibrahim EDOI: 10.12659/AJCR.927586
Am J Case Rep 2020; 21:e927586
Figure 3. Photomicrographs of the histology of the lung biopsies (day 5 of admission) in a 43-year-old man with a history of tuberculous meningitis and rifampicin pneumonitis who presented with symptoms that mimicked severe COVID-19 pneumonia with negative test results for SARS-CoV-2 infection. (A) Histology of the lung shows thickening of the alveolar walls (Red arrow) with an increase in mononuclear cells and pink hyaline membranes (Green arrows), consistent with diffuse alveolar damage (DAD) and with acute respiratory distress syndrome (ARDS) and also with rifampicin-induced pneumonitis. Hematoxylin and eosin (H&E) ×200. (B) Histology of the lung shows some residual thickening of the alveolar walls and type II pneumocyte hyperplasia without hyaline membranes. H&E ×400.