17 February 2021: Articles
Idiopathic Acquired Hemophilia A, a Rare Cause of Bleeding: A Case Report and Literature Review
Challenging differential diagnosis, Diagnostic / therapeutic accidents, Management of emergency care, Rare disease, Educational Purpose (only if useful for a systematic review or synthesis)
Carlos Andrés Regino A* , José C. Alvarez A , Leonardo Mejía Buriticá A , Natalí Uribe Pulido A , Valeria Torres Yepes A , José D. Torres ADOI: 10.12659/AJCR.929401
Am J Case Rep 2021; 22:e929401
Figure 4. Structural and functional relationship of the circulating factor VIII and the main epitopes of inhibitor autoantibodies. The circulating FVIII molecule (300 kDa, 2332 amino acid residues) is a heterodimer that consists of a heavy chain (domains A1, A2, and B) and a light chain (domains A3, C1, and C2). The regions involved in the vWF binding are within the light chain (residues 1649–1689 of the acid region 3, which precedes domain A3, residues 2181–2243, and 2303–2332 of C2 domain). The inhibitors interfere with FVIII activity through thrombin cleavage or interaction with FIXa, FX, PL, and vWF [5]. VWF, factor von Willebrand; APC, activated protein C; PL, platelet phospholipid