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15 May 2021: Articles

A 25-Year-Old Man with Refractory Schizophrenia and Clozapine-Induced Myocarditis Diagnosed by Non-Invasive Cardiovascular Magnetic Resonance

Rare disease, Adverse events of drug therapy

Tiffany Brazile B* , Amr F. Barakat E , Syed Bukhari E , Erik B. Schelbert C , Prem Soman A

DOI: 10.12659/AJCR.930103

Am J Case Rep 2021; 22:e930103

Figure 2. Cardiovascular magnetic resonance (CMR) demonstrates myocardial changes that reveal the diagnosis. (A) Late gadolinium enhancement CMR revealed acute myocarditis as evidenced by epicardial necrosis and edema of the middle and apical lateral wall (yellow arrowheads), as well as small foci of mid-myocardial necrosis in the apical septum (red arrowheads). (B) Direct T2 quantification confirmed the presence of myocardial edema indicative of acute ischemia in these regions, measuring 84.5±6.3 ms (Region 1), compared with 61.9±4.7 ms in healthy non-ischemic myocardium (Region 2). These findings support the diagnosis of clozapine-induced myocarditis.

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923