08 August 2021: Articles
Tumor-to-Tumor Metastasis: Lung Adenocarcinoma as a Recipient of Metastasis from Renal Cell Carcinoma: A Case Report
Challenging differential diagnosis, Rare coexistence of disease or pathology
Diana Caballero B , Camilo Vallejo A* , Handerson R. Osma A , Ricardo Brugés A , Harold Garcia B , Carlos Andrés Carvajal Fierro A , Carlos E. Bonilla ADOI: 10.12659/AJCR.932012
Am J Case Rep 2021; 22:e932012
Figure 4. Immunohistochemical studies with positivity for CKAE1/AE3, CK7, Napsin A, and thyroid transcription factor 1 (TTF-1) in the acinar (60%) and solid (40%) lung adenocarcinoma. Positivity for CKAE1/AE3 and CK7, and negativity for Napsin A and TTF-1 for the metastasis from the papillary renal cell carcinoma (RCC) type 2 metastasis (arrows indicate intratumoral RCC metastasis): (A) CKAE1/AE3 in the lung adenocarcinoma (CKAE1/AE3 stain, 4× magnification). (B) CKAE1/AE3 in the intratumoral metastasis of the papillary RCC type 2 (CKAE1/AE3 stain, 10× magnification). (C) CK7 in the lung adenocarcinoma (CK7 stain, 4× magnification). (D) CK7 in the intratumoral metastasis of the papillary RCC type 2 (CK7 stain, 10× magnification). (E) Napsin A in the lung adenocarcinoma (napsin A stain, 4× magnification). (F) Napsin A in the intratumoral metastasis of the papillary RCC type 2 (napsin A stain, 10× magnification). (G) TTF-1 in the lung adenocarcinoma (TTF1 stain, 4× magnification). (H) TTF-1 in the intratumoral metastasis of the papillary RCC type 2 (TTF-1 stain, 10× magnification).