17 January 2022: Articles
Adult-Onset Diamond-Blackfan Anemia with Gene Variation Case Report
Challenging differential diagnosis, Rare disease, Congenital defects / diseases, Rare coexistence of disease or pathology
Evida Mars-Holt A , Alex Murdoch E , Amanda Frugoli A* , Brian Utz E , Lynn Kong CDOI: 10.12659/AJCR.932649
Am J Case Rep 2022; 23:e932649
Figure 1. Bone marrow biopsy. (A) Bone marrow core biopsy at 10× magnification with hematoxylin and eosin staining. Normal cellularity with a predominance of myeloid cells and normal megakaryocytes. (B) Bone marrow aspirate at 20× magnification with hematoxylin and eosin staining. (C) Bone marrow core biopsy with magnification 40× with ecadherin staning. The ecadherin immunostain highlights small erythroid islands in the bone marrow core biopsy, overall decreased in number. (D) Bone marrow aspirate smear magnification 40×. This smear demonstrates predominance of myeloid. (E) Bone marrow aspirate smear magnification 100×. This smear demonstrates predominance of myeloid maturation without dysplasia and only rare erythroid precursors, consistent with erythroid hypoplasia. (F) Bone marrow aspirate smear magnification 100×. This smear demonstrates predominance of myeloid maturation without dysplasia.