Figure 3. Cervical biopsy findings: (A) One fragment of the tumor is shown here (hematoxylin and eosin; magnification 2× on Aperio Imagescope). Irregularly-sized glands with haphazard arrangement are seen in a fibrotic and inflamed stroma. Granulation tissue is seen in the left corner of the tissue. Many of the large glands are incomplete and contain inflamed mucin spilling into the tissue. (B) The tumor is composed of columnar cells with hyperchromatic pseudostratified nuclei. Occasional goblet cells (cells with increased ovoid collections of cytoplasmic basophilic mucin, often at the luminal aspect of the cell) are seen (arrowheads). These features are often seen in tumors with intestinal (enteric) differentiation. (Hematoxylin and eosin; magnification 10× on Aperio Imagescope). (C) An immunostain for CDX2 shows diffuse and strong nuclear staining in the tumor cells (anti-CDX2, clone EP25, Leica Biosystems; magnification 10× on Aperio Imagescope). (D) An immunostain for SATB2 shows diffuse nuclear staining of moderate intensity in the tumor cells (anti-SATB2, clone CL0276, Sigma Life Science; magnification 10× on Aperio Imagescope).