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02 February 2024: Articles

An AQP-4-IgG-Positive Patient with Neuroimaging Findings Suggestive of Multiple Sclerosis

Challenging differential diagnosis, Rare coexistence of disease or pathology

Mingxia Li B , Shuangxi Liu B , Jun Zhou D , Liqian Xiao B , Rongyong Man E , Junjie Yin A*

DOI: 10.12659/AJCR.942475

Am J Case Rep 2024; 25:e942475

Figure 1. MS-like (‘green flag’) and NMOSD-like (‘red flag’) MRI features of the patient. (A) Axial fluid-attenuated inversion recovery (FLAIR): Oval/round lesions, asymmetrical distribution, abutting and perpendicular to the lateral ventricles without infiltrating the white matter (MS-like). (B) Sagittal T1 without contrast: periventricular lesions perpendicular to the corpus callosum (‘Dawson’s fingers’) and black holes (MS-like). (C) Cerebral peduncles (MS-like); (D) Axial FLAIR: periependymal lesions surrounding the lateral ventricles and the third ventricle (NMOSD-like or other nonspecific lesions such as ependymitis granularis). (E) Axial FLAIR: lesions touching or within the cortex (MS-like). (F) Axial FLAIR: lesions around the fourth ventricle (NMOSD-like). (G) Sagittal T2: multiple discrete (focal) short eccentric lesions, ≤2 vertebral segments (MS-like); suspected area postrema lesions (NMOSD-like). (G’) Sagittal T2: follow-up was conducted in the first month after the end of treatment, and new lesions appeared in the cervical spinal cord (MS-like).

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923