20 April 2004
CNS leukemia in a boy diagnosed with AML-M2 with translocation t(8;21)
Unknown etiology
Ewa Wagiel, Iwona Malinowska, Barbara Sikorska-FicCase Rep Clin Pract Rev 2004; 5(null):121-125 :: ID: 12284
Abstract
Background: The gold standard for diagnosis of central nervous system (CNS) leukemia is presence of blasts in the cerebrospinal fluid (CSF) and/or paralysis of cranial nerves.Case Report: We report the case of 14-year-old male who presented with pallor, petechiae, thorax pain, fundal edema, nodules in the skin and cytopenia. Bone marrow examination revealed 20% of blasts and t(8;21). Cytology of the spinal fluid was normal but MRI showed granulocytic sarcoma and diffuse intraparenchymal and meningeal infiltration. He was diagnosed with acute myeloid leukemia (AML) FAB-M2 with translocation t(8;21) with multiple extramedullary localizations. Rapid resolution of neurological symptoms, disappearance of infiltrates on MRIand hematological remission were achieved following systemic and intrathecal chemotherapy. Initial CNS involvement lead to the subsequent CNS relapse and fatal outcome.Conclusions: CNS localization of leukemia is a major diagnostic and therapeutic problem. Imaging studies should be combined with cerebrospinal fluid examination for a more accurate diagnosis of such disease manifestation.
Keywords: t(8;21), CNS leukemia, AML, MRI
25
In Press
12 Feb 2024 : Case report
Diagnostic Challenges and Imaging Considerations for Intraparotid Facial Nerve Schwannoma: A Case Report an...Am J Case Rep In Press; DOI: 10.12659/AJCR.942870
12 Feb 2024 : Case report
Erdheim-Chester Disease Occult on Radiographs and CT but Visible on MRI and PETAm J Case Rep In Press; DOI: 10.12659/AJCR.941169
12 Feb 2024 : Case report
Surgical Treatment of Spontaneous Superficial Temporal Artery Arteriovenous Malformation: A Case ReportAm J Case Rep In Press; DOI: 10.12659/AJCR.942839
13 Feb 2024 : Case report
Warfarin Woes: A Rare Case of Hemoperitoneum with Intramural Small Bowel HematomaAm J Case Rep In Press; DOI: 10.12659/AJCR.943519
Most Viewed Current Articles
10 Jan 2022 : Case report
A Report on the First 7 Sequential Patients Treated Within the C-Reactive Protein Apheresis in COVID (CACOV...DOI :10.12659/AJCR.935263
Am J Case Rep 2022; 23:e935263
19 Jul 2022 : Case report
Atlantoaxial Subluxation Secondary to SARS-CoV-2 Infection: A Rare Orthopedic Complication from COVID-19DOI :10.12659/AJCR.936128
Am J Case Rep 2022; 23:e936128
05 Mar 2022 : Case report
Acute Limb Ischemia After Self-Injection of Crushed Morphine Tablets into the Radial Artery: Role of Infrar...DOI :10.12659/AJCR.935336
Am J Case Rep 2022; 23:e935336
02 Apr 2022 : Case report
Infective Endocarditis Caused by Pseudomonas luteola in a Pediatric Patient. A Case Report and Review of Li...DOI :10.12659/AJCR.935743
Am J Case Rep 2022; 23:e935743