Logo American Journal of Case Reports

Call: 1.631.629.4328
Mon-Fri 10 am - 2 pm EST

Contact Us

Logo American Journal of Case Reports Logo American Journal of Case Reports Logo American Journal of Case Reports

20 April 2004

CNS leukemia in a boy diagnosed with AML-M2 with translocation t(8;21)

Unknown etiology

Ewa Wagiel, Iwona Malinowska, Barbara Sikorska-Fic

Case Rep Clin Pract Rev 2004; 5(null):121-125 :: ID: 12284

Abstract

Background: The gold standard for diagnosis of central nervous system (CNS) leukemia is presence of blasts in the cerebrospinal fluid (CSF) and/or paralysis of cranial nerves.Case Report: We report the case of 14-year-old male who presented with pallor, petechiae, thorax pain, fundal edema, nodules in the skin and cytopenia. Bone marrow examination revealed 20% of blasts and t(8;21). Cytology of the spinal fluid was normal but MRI showed granulocytic sarcoma and diffuse intraparenchymal and meningeal infiltration. He was diagnosed with acute myeloid leukemia (AML) FAB-M2 with translocation t(8;21) with multiple extramedullary localizations. Rapid resolution of neurological symptoms, disappearance of infiltrates on MRIand hematological remission were achieved following systemic and intrathecal chemotherapy. Initial CNS involvement lead to the subsequent CNS relapse and fatal outcome.Conclusions: CNS localization of leukemia is a major diagnostic and therapeutic problem. Imaging studies should be combined with cerebrospinal fluid examination for a more accurate diagnosis of such disease manifestation.

Keywords: t(8;21), CNS leukemia, AML, MRI

Add Comment 0 Comments

25

In Press

12 Feb 2024 : Case report  Germany

Diagnostic Challenges and Imaging Considerations for Intraparotid Facial Nerve Schwannoma: A Case Report an...

Am J Case Rep In Press; DOI: 10.12659/AJCR.942870  

0:00

12 Feb 2024 : Case report  USA

Erdheim-Chester Disease Occult on Radiographs and CT but Visible on MRI and PET

Am J Case Rep In Press; DOI: 10.12659/AJCR.941169  

0:00

12 Feb 2024 : Case report  USA

Surgical Treatment of Spontaneous Superficial Temporal Artery Arteriovenous Malformation: A Case Report

Am J Case Rep In Press; DOI: 10.12659/AJCR.942839  

13 Feb 2024 : Case report  Bahrain

Warfarin Woes: A Rare Case of Hemoperitoneum with Intramural Small Bowel Hematoma

Am J Case Rep In Press; DOI: 10.12659/AJCR.943519  

Most Viewed Current Articles

10 Jan 2022 : Case report  Germany

A Report on the First 7 Sequential Patients Treated Within the C-Reactive Protein Apheresis in COVID (CACOV...

DOI :10.12659/AJCR.935263

Am J Case Rep 2022; 23:e935263

19 Jul 2022 : Case report  Saudi Arabia

Atlantoaxial Subluxation Secondary to SARS-CoV-2 Infection: A Rare Orthopedic Complication from COVID-19

DOI :10.12659/AJCR.936128

Am J Case Rep 2022; 23:e936128

05 Mar 2022 : Case report  Brazil

Acute Limb Ischemia After Self-Injection of Crushed Morphine Tablets into the Radial Artery: Role of Infrar...

DOI :10.12659/AJCR.935336

Am J Case Rep 2022; 23:e935336

02 Apr 2022 : Case report  Saudi Arabia

Infective Endocarditis Caused by Pseudomonas luteola in a Pediatric Patient. A Case Report and Review of Li...

DOI :10.12659/AJCR.935743

Am J Case Rep 2022; 23:e935743

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923