Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

20 May 2003

Late relapse of hepatoblastoma in children –case report

E. Rogowska, M. Rychłowska, W. Woźniak

Med Sci Monit 2003; 9(2): 15-0 :: ID: 15271

Abstract

Background:We would like to present two patients in our hospital for hepatoblastoma,both with late relapse diagnosed.Case Report:Patient No 1.3 8/12-year old girl was treated for liver left lobe hepatoblastoma at the age of 15 months.The level of AFP before the treatment ’s beginning was 428 400 JU/ml.The tumor was situated in the whole epigastric region and was also palpable in pelvis.The patient was qualified to the chemotherapy according to SIOPEL protocol.She received 3 course of treatment:1CDDP-80 mg/sqm,and 3 courses of PLADO (ADM/CDDP).AFP decreased to the level of 199.76 IU/ml. Afterwards the surgical procedure of the tumor ’s resection was perfomed. Histological examination has proved total tumor necrosis;alive neoplastic cells were found only in satellite module and in the lymph node.Application of 2 course of PLADO followed the operation and led to treatment completion.14 months after the treatment ’s end the local relapse in the left lobe of the liver with increase of AFP to the level of 767,79 was diagnosed. Chemotherapy with high doses of CTX (due to SIOPEL protocol)was introduced.There was no response to this treatment.Therefore chemotherapy was changed –the patient received 1 course of CBDCA/VP-16 –without any response again.Hence the chemotherapy was changed again –2 courses of ADM/CDDP were administred.The level of AFP decreased, which allowed performing a surgical resection of the right liver lobe.Histological examination has proved live neoplastic cells in the whole tumor; neoplastic cells were also present in the blood vessels.Due to this result the treatment was changed again –the patient received combined chemotherapy:CDDP, 5FU,VCR.The girl received 2 courses of this therapy and still is being treated in our hospital. Patient No 2.4-year old girl treated from the age of 12 months or left liver lobe hepatoblastoma.The level of AFP before treatment ’s beginning was 595 000 UI/ml.The tumor was diagnosed as inoperalbc.The patient was qualified to the chemotherapy according to SIOPEL protocol.She received 5 course of CDDP in dose of 80 mg/m 2 and 3 courses of PLADO. AFP level decreased to 4 000 IU/ml.The surgical procedure of the tumor ’s resection was perfomed.Histological examination has proved tumor necrosis in 50%,the operation waw not adical,neoplastic cells were present in blood vessels. Chemotherapy was being continued and the girl received 4 courses of PLADO,what completed the treatment.35 months after the treatment ’s and a relapse in the right lobe of the liver was diagnosed.Additionally metastases in the right lung was suspected.AFP –46 020 IU/ml.Chemotherapy with high doses of CTX according to SIOPEL was administered.After 2 courses there was no response to the reatment.Chemotherapy was changed –the patient received 1 course of CBDCA/VP-16- also without any response.Afterwards chemotherapy with ADM/CDDP according to SIOPEL was administred.A positive response towards treatment has been obtained –AFP decreased to the level of 845 IU/ml.The patient is still treated in our hospital.Conclusions:1.The patient after completed treatment for hepatoblastoma should be observed for the long time because of a high risk of late relapses. 2.If the radicality of surgery procedure is doubtful it seems to be advisable to adhibit local radiotherapy.

Add Comment 0 Comments

Editorial

01 March 2024 : Editorial  

Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-Thalassemia

Dinah V. Parums

DOI: 10.12659/MSM.944204

Med Sci Monit 2024; 30:e944204

0:00

In Press

21 Feb 2024 : Clinical Research  

Potential Value of HSP90α in Prognosis of Triple-Negative Breast Cancer

Med Sci Monit In Press; DOI: 10.12659/MSM.943049  

22 Feb 2024 : Review article  

Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943168  

23 Feb 2024 : Clinical Research  

A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943732  

26 Feb 2024 : Clinical Research  

Predictive Value of Combined HbA1c and Neutrophil-to-Lymphocyte Ratio for Diabetic Peripheral Neuropathy in...

Med Sci Monit In Press; DOI: 10.12659/MSM.942509  

Most Viewed Current Articles

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750