12 March 2002
Determination of lactic acid level in systemic liquids in children with progressiveencephalopathies.
Katarzyna Wojaczyńska-Stanek, Jerzy Pietruszewski, Elzbieta Marszał, Ewa Emich-Widera, Eugenia Bielińska-BujniewiczMed Sci Monit 2002; 8(3): CR217-222 :: ID: 420888
Abstract
BACKGROUND: This article reports the results of research into the activitiesof lactic acid concentrations in the body fluids of children with progressive encephalopathies (PE) incomparison to patients with non-progressive encephalopathies (NPE) and those with non-progressive encephalopathieswith concomitant epilepsy (NPEE). The study was designed to determine whether there is difference betweenthe serum and CSF lactic acid concentrations in children with progressive encephalopathies (PE), static(non-progressive) encephalopathies (NPE) and non progressive encephalopathies with concomitant epilepsy(NPEE), and whether the clinical status correlates with the concentration of these biochemical markersin children with PE. MATERIAL/METHODS: The assessment involved 138 children of both sexes, whose ageranged between 8 months and 15 years, diagnosed and treated in the Neurology Department at the PediatricClinic of the Silesian Medical Academy in Katowice between 1995 and 1997. Lactate concentrations weredetermined in serum and cerebro-spinal fluid and analyzed statistically. RESULTS: The findings showedhigher serum and CSF concentrations in children with PE than in patients who manifested non-progressiveforms of encephalopathy. The degree of clinical symptom aggravation in PE children was likewise analyzedand compared to the values of lactate concentrations in body fluids; however, no correlation was foundbetween these parameters. CONCLUSIONS: Children with progressive encephalopathies present higher lactateconcentrations in serum and cerebrospinal fluid than patients with static (non-progressive) encephalopathy.
Keywords: Adolescent, Brain Diseases, Case-Control Studies, Cerebrovascular Disorders, Child, Child, Preschool, Epilepsy, Lactic Acid
Editorial
01 March 2024 : Editorial
Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-ThalassemiaDOI: 10.12659/MSM.944204
Med Sci Monit 2024; 30:e944204
In Press
21 Feb 2024 : Clinical Research
Potential Value of HSP90α in Prognosis of Triple-Negative Breast CancerMed Sci Monit In Press; DOI: 10.12659/MSM.943049
22 Feb 2024 : Review article
Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...Med Sci Monit In Press; DOI: 10.12659/MSM.943168
23 Feb 2024 : Clinical Research
A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...Med Sci Monit In Press; DOI: 10.12659/MSM.943732
26 Feb 2024 : Clinical Research
Predictive Value of Combined HbA1c and Neutrophil-to-Lymphocyte Ratio for Diabetic Peripheral Neuropathy in...Med Sci Monit In Press; DOI: 10.12659/MSM.942509
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952