01 January 2000
Effect of melatonin on two stage skin carcinogenesis in Swiss mice.
Arun C. Kumar, Unduri N. DasMed Sci Monit 2000; 6(3): BR471-475 :: ID: 421324
Abstract
Melatonin, a hormone secreted by the pineal gland, is known to have anti-mutagenicand oncostatic actions. This beneficial action of melatonin has been explained in terms of its abilityto scavenge free radicals and augment the activities of anti-oxidant enzymes. In the present study, weevaluated the effect of melatonin on benzo(a)pyrene-induced two stage skin carcinogenesis in mice andobserved that it can not only decrease the number of animals bearing papillomas but also the number ofpapillomas per animal both in the initiation and promotion stages of skin carcinogenesis. It was alsofound that melatonin treated animals have low levels of lipid peroxides and that it can also preventthe binding of BP or its metabolites to DNA. In view of these evidence, it can be suggested that melatoninmay function as an endogenous anti-mutagenic and oncostatic agent.
Keywords: Anticarcinogenic Agents, Benzo(a)pyrene, Croton Oil, DNA, Melatonin, Papilloma, Skin, Skin Neoplasms, Thymidine
Editorial
01 May 2024 : Editorial
Editorial: First Regulatory Approval for Adoptive Cell Therapy with Autologous Tumor-Infiltrating Lymphocytes (TILs) – Lifileucel (Amtagvi)DOI: 10.12659/MSM.944927
Med Sci Monit 2024; 30:e944927
In Press
14 Mar 2024 : Clinical Research
Renal Dysfunction Increases Risk of Adverse Cardiovascular Events in 5-Year Follow-Up Study of Intermediate...Med Sci Monit In Press; DOI: 10.12659/MSM.943956
15 Mar 2024 : Clinical Research
Impact of One-Lung Ventilation on Oxygenation and Ventilation Time in Thoracoscopic Heart Surgery: A Compar...Med Sci Monit In Press; DOI: 10.12659/MSM.943089
14 Mar 2024 : Clinical Research
Differential DHA and EPA Levels in Women with Preterm and Term Births: A Tertiary Hospital Study in IndonesiaMed Sci Monit In Press; DOI: 10.12659/MSM.943895
15 Mar 2024 : Clinical Research
Evaluation of an Optimized Workflow for the Radiofrequency Catheter Ablation of Paroxysmal Atrial FibrillationMed Sci Monit In Press; DOI: 10.12659/MSM.943526
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952