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Medical Science Monitor Basic Research


The results of specific diagnostic methods in patients with pollinosis treated by specific immunotherapy

Marek Modrzyński, Edward Zawisza

CaseRepClinPractRev 2004; 5:520-528

ID: 428989

Available online:


Background: In addition to allergen elimination, specific immunotherapy remains the only recognized causal treatment of allergic diseases. Nevertheless, there are no commonly accepted parameters and tests allowing for the evaluation and prediction of its efficacy. The aim of this study was to evaluate the results of readily available supplemental allergy tests and to attempt to associate those findings with the outcome of therapy for desensitized patients. Material/Methods: This study was conducted in a group of 28 patients receiving specific immunotherapy for seasonal allergic rhinitis to tree pollen. The results of skin prick tests, sIgE levels, nasal eosinophilia levels as well as specific nasal provocation tests measured by acoustic rhinometry were compared prior to desensitization and two years following the therapy. The control group comprised 17 allergic patients treated without immunotherapy. Results: Apart from the confirmation of immunotherapy efficacy, a positive correlation between its results and the results of the nasal provocation test (p=0.0001) as well as nasal eosinophilia (p=0,025) were demonstrated in this study. No relationship was however found between the obtained result and the results of skin prick tests or serum sIgE levels. The result of acoustic rhinometry corresponded well with clinical manifestations observed in nasal provocation tests. Conclusions: The specific nasal provocation test is an easy method that may be used for monitoring the efficacy of the immunotherapy, and acoustic rhinometry is a good method for measuring its results.

Keywords: specific immunotherapy, Diagnostic methods, allergic rhinitis