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Medical Science Monitor Basic Research


Multiple cranial nerve palsies: a rare initial presentation of adult aleukaemic acute lymphoblastic leukaemia

Vijaya Bhaskar Reddy Sagili, Jeevana Nilkund, Debdatta Basu

CaseRepClinPractRev 2004; 5:542-544

ID: 428993

Available online:


Background: Meningeal syndrome during the course of acute lymphoblastic leukaemia (ALL), especially in children, is well recognized. Multiple cranial nerve palsies as the initial presentation of aleukaemic ALL in adults is, however, rare.Case Report: A 27-year-old male patient presented with multiple cranial nerve palsies. There was no lymphadenopathy or hepatosplenomegaly. Peripheral blood smear didnot reveal any blasts. There were atypical lymphoid cells in the cerebrospinal fluid. Bone marrow aspiration done subsequently revealed aleukaemic ALL.Conclusions: The case is reported for the rarity of cranial nerve palsies including ninth and tenth nerve palsies in adult aleukaemic ALL.

Keywords: Cranial nerve palsies, aleukaemic leukaemia, acute lymphoblastic leukaemia, bulbar palsy