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Medical Science Monitor Basic Research


Myelonecrosis – clinicopathological significance of a rare bone marrow lesion

Debdatta Basu, Parasappa Yaranal

CaseRepClinPractRev 2005; 6:261-264

ID: 429695

Available online:


Background: Myelonecrosis is a rare ante-mortem finding and reported in a wide range of disorders.
Case Report: Seven cases of myelonecrosis were diagnosed in a period of four years, accounting for 0.58% of bone marrow trephine biopsies done in this period. A detailed clinical and hematological profile
was studied in each case.The diseases associated with marrow necrosis were varied and included metastatic carcinoma, acute leukaemia, post chemotherapy in a case of non-Hodgkin’s lymphoma and tuberculosis.Three patients had acquired immunodeficiency syndrome. Thrombocytopenia, anemia and leucoerythroblastic blood picture were common hematological abnormalities. Three patients died shortly after the diagnosis was made.
Conclusions: Myelonecrosis or bone marrow necrosis is an uncommon finding in bone marrow biopsies.Presence of necrosis in marrow is usually associated with an underlying disease and has a poor prognosis.

Keywords: Myelonecrosis, Bone Marrow, trephine biopsy