01 January 2005
Infliximab and surgical therapy in a patient with severe crohn’s disease: a case report
Zsolt Barta, Zsuzsa Ress, Zoltán Csiki, Katalin Dévényi, László Buris, László Tóth, Margit ZeherCase Rep Clin Pract Rev 2005; 6:281-284 :: ID: 438975
Abstract
Background: The treatment with infliximab is highly effective in refractory and fistulising Crohn’s disease. As Crohn’s disease represents a major challenge for surgery and since the conservative therapeutical approach with anti-TNF antibodies always requires consideration of potential benefits and risks for the patient as well, the optimal treatment requires a close interdisciplinary approach.
Case Report: Here we describe the case of a young male with a history of rapidly manifesting Crohn’s disease(and unrecognized celiac disease) whose conflicting findings presented dilemma to use infliximab in consideration of its contraindications. After multilateral discussions with specialists and judicious revision of his results, the patient was treated successfully and minimal surgical intervention was needed instead of heroic surgery. A minority of patients with celiac disease who fail to respond to a gluten-free diet may require therapy with immunomodulating drugs. Our patient’s remission
was not induced by infliximab but with gluten-free diet.
Conclusions: A 2-year follow-up demonstrated distinct improvement. Celiac disease poses a therapeutic challenge to clinicians and carefully selected patients may benefit from anti-TNF therapy although our experience does not strengthen this concept.
Keywords: Crohn’s disease, celiac disease, Surgery, infliximab
21
In Press
12 Feb 2024 : Case report
Erdheim-Chester Disease Occult on Radiographs and CT but Visible on MRI and PETAm J Case Rep In Press; DOI: 10.12659/AJCR.941169
12 Feb 2024 : Case report
Surgical Treatment of Spontaneous Superficial Temporal Artery Arteriovenous Malformation: A Case ReportAm J Case Rep In Press; DOI: 10.12659/AJCR.942839
13 Feb 2024 : Case report
Warfarin Woes: A Rare Case of Hemoperitoneum with Intramural Small Bowel HematomaAm J Case Rep In Press; DOI: 10.12659/AJCR.943519
13 Feb 2024 : Case report
Hemorrhagic Presentation in Primary Central Nervous System Lymphoma: A Case StudyAm J Case Rep In Press; DOI: 10.12659/AJCR.942951
Most Viewed Current Articles
07 Mar 2024 : Case report
Neurocysticercosis Presenting as Migraine in the United StatesDOI :10.12659/AJCR.943133
Am J Case Rep 2024; 25:e943133
10 Jan 2022 : Case report
A Report on the First 7 Sequential Patients Treated Within the C-Reactive Protein Apheresis in COVID (CACOV...DOI :10.12659/AJCR.935263
Am J Case Rep 2022; 23:e935263
19 Jul 2022 : Case report
Atlantoaxial Subluxation Secondary to SARS-CoV-2 Infection: A Rare Orthopedic Complication from COVID-19DOI :10.12659/AJCR.936128
Am J Case Rep 2022; 23:e936128
23 Feb 2022 : Case report
Penile Necrosis Associated with Local Intravenous Injection of CocaineDOI :10.12659/AJCR.935250
Am J Case Rep 2022; 23:e935250