Logo American Journal of Case Reports

Call: 1.631.629.4328
Mon-Fri 10 am - 2 pm EST

Contact Us

Logo American Journal of Case Reports Logo American Journal of Case Reports Logo American Journal of Case Reports

01 January 2005

Inflammatory Myofibroblastic Tumor of the Pancreas: Immunohistochemical Analysis of a Case and Review of the Literature

Hirozumi Sawai, Yuji Okada, Hitoshi Funahashi, Yoichi Matsuo, Hiroki Takahashi, Hiromitsu Takeyama, Tadao Manabe

Case Rep Clin Pract Rev 2005; 6:354-359 :: ID: 440503

Abstract

Background: The aim of this study is to investigate the clinicopathological characteristics of inflammatory myofibroblastic tumor (IMT) of the pancreas.
Case Report: We present herein a case of IMT of the pancreas in a 51-year-old man with immunohistochemical
analysis and a review of the IMT in the English literature. A 51-year-old Japanese man was
diagnosed as carcinoma of the pancreatic head and he underwent a pylorus-ring preserving
pancreatoduodenectomy. The pathological diagnosis was IMT. The immunohistochemical examination revealed that although the p53 protein test was negative, tests for alpha-smooth muscle actin, desmin, and vimentin were positive in spindle cells. A majority of spindle cells in this tumor also stained for neuron specific enolase and S-100 protein. Strong positive immunostaining for the α[sub]6[/sub]- and β[sub]1[/sub]-integrin subunits, interleukin-1 receptor type I, the nuclear factor-kappaB p65 subunit and proliferating cell nuclear antigen was found in a majority of the spindle cells. These immunohistochemical results suggested the possibility that the IMT in this patient had a malignant.
Conclusions: This case gave us some difficulty, and the correct diagnosis of the pancreatic tumor was valuable. To diagnose the malignant potential of this type of tumor accurately may have value to direct
the appropriate therapeutic operations after surgery and postoperative progress observation.

Keywords: inflammatory myofibroblastic tumor, Integrins, interleukin-1 receptor type I

0 Comments

SARS-CoV-2/COVID-19

19 May 2022 : Case report  Serbia

Bilateral Emphysematous Pyelonephritis Associated with COVID Pneumonia: A Case Report

Am J Case Rep In Press; DOI: 10.12659/AJCR.936370  

17 May 2022 : Case report  USA

High-Frequency Oscillatory Ventilation for Refractory Hypoxemia in Severe COVID-19 Pneumonia: A Small Case ...

Am J Case Rep In Press; DOI: 10.12659/AJCR.936651  

13 May 2022 : Case report  Japan

A case of exacerbation of haloperidol-induced rhabdomyolysis following the onset of COVID-19

Am J Case Rep In Press; DOI: 10.12659/AJCR.936589  

13 May 2022 : Case report  USA

Acute Disseminated Encephalomyelitis After SARS-CoV-2 Vaccination

Am J Case Rep In Press; DOI: 10.12659/AJCR.936574  

In Press

20 May 2022 : Case report  Canada

Diagnostic Puzzle of Acute Ischemic Stroke Mimics – Seizure Versus Post-Stroke Recrudescence: A Case Report

Am J Case Rep In Press; DOI: 10.12659/AJCR.936826  

19 May 2022 : Case report  Saudi Arabia

Extremes of Anemia: The Lowest Hemoglobin Values Probably Ever Reported in the Pediatric Literature Attribu...

Am J Case Rep In Press; DOI: 10.12659/AJCR.936252  

19 May 2022 : Case report  Brazil

Acute Hepatitis with Positive Autoantibodies: A Case of Natalizumab-Induced Early-Onset Liver Injury

Am J Case Rep In Press; DOI: 10.12659/AJCR.936318  

19 May 2022 : Case report  Japan

Successful Percutaneous Fogarty Thrombectomy for Subacute Lower Limb Ischemia Due to Resistant Thrombus in ...

Am J Case Rep In Press; DOI: 10.12659/AJCR.936377  

Most Viewed Current Articles

31 Dec 1969 : Case report  USA

Penile Necrosis Associated with Local Intravenous Injection of Cocaine

DOI :10.12659/AJCR.935250

Am J Case Rep 2022; 23:e935250

31 Dec 1969 : Case report  Oman

Myocarditis, Pulmonary Hemorrhage, and Extensive Myositis with Rhabdomyolysis 12 Days After First Dose of P...

DOI :10.12659/AJCR.934399

Am J Case Rep 2022; 23:e934399

31 Dec 1969 : Case report  Brazil

Lipedema Can Be Treated Non-Surgically: A Report of 5 Cases

DOI :10.12659/AJCR.934406

Am J Case Rep 2021; 22:e934406

31 Dec 1969 : Case report  USA

A Rare Case of Coronavirus Disease 2019 Vaccine-Associated Cerebral Venous Sinus Thrombosis Treated with Me...

DOI :10.12659/AJCR.935355

Am J Case Rep 2022; 23:e935355

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923