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Medical Science Monitor Basic Research


Fatal course of acute monocytic leukemia at second trimester of pregnancy

Mehmet Vural, Birsen Unsal Koyuncu, Muhammed Emin Akkoyunlu, Hamit Alper Tanriverdi

CaseRepClinPractRev 2006; 7:216-219

ID: 456858

Available online:


Background: Leukemia is a rarely encountered disease during pregnancy, and it is hard to manage. Acute
myeloid leukemia accounts for almost 60% of all leukemias during pregnancy. It is related with
poor prognosis for both pregnant and the fetus. Treatment strategies differ according to the
gestational week. Without considering pregnancy at all weeks, immediate appropriate treatment is advised.
Case Report: We present a case of acute monocytic leukemia which is diagnosed at 17th week of gestation.
Patient has been referred because of thrombocytopenia and leukocytosis during pregnancy. Although proper treatment was initiated immediately after the diagnosis, patient died due to progression of disease in few days, probably due to intracranial hemorrhage.
Conclusions: Thrombocytopenia and leukocytosis are important signs of the hematological malignancy and
needs urgent management.

Keywords: Acute monocytic leukemia, Pregnancy, Thrombocytopenia, Leukocytosis