01 December 2002
Essential thrombocythemia – etiology and clinical course
Krzysztof Pałgan, Andrzej Dziedziczko, Elżbieta Kremplewska-Należyta, Izabela PałganCase Rep Clin Pract Rev 2002; 3(4):276-280 :: ID: 474494
Abstract
Essential thrombocythemia (ET) belongs to myeloproliferative syndromes. It has a multifactor etiology. Dark hair dyes, benzene, electromegnetic radiation, infections with RNA viruses and genetic predispositions have been
found to contribute to transformation of thrombocyte precursor cells. The most common complications of clonal thrombocytic proliferation are thrombosis, embolism and hemorrhages. The drugs most frequently used
in treatment of the condition include hydroxyurea, anagrelide, interferon-alpha, melphalan, radioactive phosphorus, busulfan, chlorambucil, aspirin and dipyridamol.
Keywords: myeloproliferative syndrome, essential thrombocythemia, etiology, clinical presentation
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