H-Index
17
Scimago Lab
powered by Scopus
eISSN: 1941-5923
call: +1.631.629.4328
Mon-Fri 10 am - 2 pm EST

Logo

MSMbanner
Medical Science Monitor Basic Research

Annals
ISI-Home

Prospects for treatment of HIV1 viral infections

Patryk Smoliński

CaseRepClinPractRev 2001; 2(4):295-304

ID: 475351

Available online:

Published:


The latest revelation of the HIV1 natural history infection has made more aspects of the virus entry into cells more comprehensible. It is described as a multistage process with a key role of receptors and coreceptors. Succeeding binding of the structures launches a conformational casacade leading to virus-cell membrane fusion. Isolation of particles effectively blocking the process could enable creating new classes of antiretroviral drugs with a completely different way of affecting the virus. Certain prototype structures have already resulted to be successful - mostly according to in vitro research. However, further studies concerning in vivo analysis-which has partly been pursued-seems to be very promising, as well.

Keywords: HIV1, AIDS, fusion, Chemokines



Back