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Non-autoimmune polyglandular deficiency – case report

Jan Ruxer, Michał Możdżan, Agnieszka Siejka, Jerzy Loba, Leszek Markuszewski

CaseRepClinPractRev 2007; 8:200-202

ID: 498171

Available online:

Published: 2007-08-27

Background: Autoimmune polyglandular syndromes (APS) are rare diseases and are characterized by the association of at least two endocrine disorders of autoimmune origin. There is usually a long time interval between the subsequent endocrine diseases development and they occur in different subsequency. Contrary to the studies on the association between type 1
diabetes mellitus and other autoimmune disorders, little is known about the prevalence of other types of diabetes in subjects with APS.
Case Report: We demonstrate 76-year-old woman with Addison’s disease diagnosed 33 years ago. In 1991 the patient was diagnosed as type 2 diabetes mellitus and treated with oral hypoglycaemic agents for over 8 years, followed in 1999 by insulin therapy. In June 2003, the female was admitted to the Diabetology Department due to increased thirst, polyuria and weakness.
On the ground of the clinical symptoms and the measurements of thyroid hormones hypothyreosis was diagnosed and L-thyroxine 25 μg/day once daily was started. Antithyroid peroxidase, thyroglobulin and anti-TSH receptor antibodies’ values were 294 U/ml,

Keywords: Diabetes Mellitus, Hypothyroidism, Addison Disease