20 May 2008
Severe unexplained HIV seronegative immune suppression (SUHIS) with invasive aspergillosis and candidiasisOmotayo Olatinwo, Chinedu Ivonye, Uma Jamched, Madiha Khan, Francene Warner, Eric Flenaugh
Am J Case Rep 2008; 9:280-284 :: ID: 858184
Background: HIV/AIDS infection is typically associated with a low CD4 count. In general CD4 count is a marker of clinical progression and management of the disease. HIV/AIDS is also associated with CD4/CD8 ratio of less than 1 and hypergammaglobulinemia. Emerging reports of CD4 lymphopenia in the absence of evidence of HIV -1 or HIV -2 infections led to a new clinical entity called Severe Unexplained HIV- seronegative immune suppression( SUHIS) by the World Health Organization. We report a case of SUHIS in a 30 year old man with Invasive Aspergillosis and Candidiasis.
Case Report: A 30 year-old-male with no significant past medical history presented with worsening right sided chest pain, productive cough, and shortness of breath of two weeks duration. He was incarcerated few months prior to presentation where he had a negative PPD and HIV test. He reported a 15 pack year history of cigarette smoking in addition to smoking “rolled up tissue paper” in jail. After initial investigations, he was found to have right cavitary lung lesions secondary to invasive aspergillosis, oropharyngeal candidiasis and a very low CD4 count which was suggestive of immunosuppression. Further investigations confirmed his diagnosis of SUHIS. He was treated with fluconazole for candidiasis and amphotericin/voriconazole for aspergillosis.
Conclusions: SUHIS is defi ned exclusively by CD4 count of less than 300/mcL or < 20% of total T cells on two occasions, in the absence of HIV infection and the presence of opportunistic infection, indicative of cellular immune defi ciency.
Keywords: Aspergillosis, CD4 depletion, CD4/CD8 ratio, AIDS/HIV, immunosuppresion
19 May 2022 : Case reportBilateral Emphysematous Pyelonephritis Associated with COVID Pneumonia: A Case Report
Am J Case Rep In Press; DOI: 10.12659/AJCR.936370
17 May 2022 : Case reportHigh-Frequency Oscillatory Ventilation for Refractory Hypoxemia in Severe COVID-19 Pneumonia: A Small Case ...
Am J Case Rep In Press; DOI: 10.12659/AJCR.936651
13 May 2022 : Case reportA case of exacerbation of haloperidol-induced rhabdomyolysis following the onset of COVID-19
Am J Case Rep In Press; DOI: 10.12659/AJCR.936589
23 May 2022 : Case reportPharmacological and Behavioral Strategies to Improve Vision in Acquired Pendular Nystagmus
Am J Case Rep In Press; DOI: 10.12659/AJCR.935148
23 May 2022 : Case reportA Case of Methicillin-Sensitive Staphylococcus aureus (MSSA) Prostate Abscess, Osteomyelitis, and Myositis ...
Am J Case Rep In Press; DOI: 10.12659/AJCR.936704
23 May 2022 : Case reportAdalimumab Mitigates Lumbar Radiculopathy in a Case of Ankylosing Spondylitis
Am J Case Rep In Press; DOI: 10.12659/AJCR.936600
Most Viewed Current Articles
23 Feb 2022 : Case reportPenile Necrosis Associated with Local Intravenous Injection of Cocaine
Am J Case Rep 2022; 23:e935250
17 Feb 2022 : Case reportMyocarditis, Pulmonary Hemorrhage, and Extensive Myositis with Rhabdomyolysis 12 Days After First Dose of P...
Am J Case Rep 2022; 23:e934399
06 Dec 2021 : Case reportLipedema Can Be Treated Non-Surgically: A Report of 5 Cases
Am J Case Rep 2021; 22:e934406