01 September 2008
Am J Case Rep 2008; 9:371-374 :: ID: 868001
Background: A steatohepatitis in Multiple Myeloma which is caused by drug induced chemotherapy ussually appear after using the chemotherapy agents. However, the steatohepatitis which is caused by re-exposure and accumulating dose of cyclophosphamide + dexamethasone, and the clinical symptoms which are appeared after several months discontinuing chemotherapy is a rare case.
Case Report: A 41-year-old man with relapsed of Mutiple Myeloma (MM) grade III suffered non-alcoholic steatohepatitis (NASH) 10 months after discontinuing chemoteraphy agents (cyclophosphamide 400 mg + dexamethason 40 mg day 1–4; 5 cycles). A diagnosis of NASH is performed based on increasing of transaminase enzymes, negative serology tests of hepatitis viral (HBsAg and anti-HCV), normal iron status, a bright liver on liver ultrasound feature and liver biopsy which the result of histological examination (H&E) showed steatosis grade 3 with steatohepatitis grade 2 and fibrosis grade 2.
Conclusions: We reported a moderate steatohepatitis and mild fibrosis patient that is caused by chemotherapy agents (cyclophosphamine + dexamethasone). The clinical symptoms appeared after 10 months of discontinuing chemotherapy.
Keywords: non alcoholic steatohepatitis, Multiple Myeloma, cyclophospamide, Dexamethason
19 May 2022 : Case reportBilateral Emphysematous Pyelonephritis Associated with COVID Pneumonia: A Case Report
Am J Case Rep In Press; DOI: 10.12659/AJCR.936370
17 May 2022 : Case reportHigh-Frequency Oscillatory Ventilation for Refractory Hypoxemia in Severe COVID-19 Pneumonia: A Small Case ...
Am J Case Rep In Press; DOI: 10.12659/AJCR.936651
13 May 2022 : Case reportA case of exacerbation of haloperidol-induced rhabdomyolysis following the onset of COVID-19
Am J Case Rep In Press; DOI: 10.12659/AJCR.936589
23 May 2022 : Case reportPharmacological and Behavioral Strategies to Improve Vision in Acquired Pendular Nystagmus
Am J Case Rep In Press; DOI: 10.12659/AJCR.935148
23 May 2022 : Case reportA Case of Methicillin-Sensitive Staphylococcus aureus (MSSA) Prostate Abscess, Osteomyelitis, and Myositis ...
Am J Case Rep In Press; DOI: 10.12659/AJCR.936704
23 May 2022 : Case reportAdalimumab Mitigates Lumbar Radiculopathy in a Case of Ankylosing Spondylitis
Am J Case Rep In Press; DOI: 10.12659/AJCR.936600
Most Viewed Current Articles
23 Feb 2022 : Case reportPenile Necrosis Associated with Local Intravenous Injection of Cocaine
Am J Case Rep 2022; 23:e935250
17 Feb 2022 : Case reportMyocarditis, Pulmonary Hemorrhage, and Extensive Myositis with Rhabdomyolysis 12 Days After First Dose of P...
Am J Case Rep 2022; 23:e934399
06 Dec 2021 : Case reportLipedema Can Be Treated Non-Surgically: A Report of 5 Cases
Am J Case Rep 2021; 22:e934406