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Medical Science Monitor Basic Research


Plasmablastic plasmacytoma of the sinonasal cavity with early metastases to the skin

Georges Hatoum, Cristiane Takita, May Abdel-Wahab, Margaret Demars, Cy Lee

Am J Case Rep 2009; 10:221-223

ID: 878288

Available online:

Published: 2009-12-01


Background: Plasmablastic plasmacytoma of the head neck is a very rare entity with an aggressive behavior.
Case Report: We describe a caucasian man with extramedullary plasmacytoma involving the sinonasal cavity, and stress the importance of the histological subtype of plasma cells on overall prognosis.
Conclusions: Our case illustrates the importance of the histological subtype of extramedullary plasmacytoma. The morphology of the plasma cell is a relevant prognostic marker. Immature and plasmablastic plasma cells are associated with a poor prognosis and early systemic involvement.

Keywords: extramedullary plasmacytoma, head and neck carcinoma , radiation therapy