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Medical Science Monitor Basic Research


Simultaneous diagnosis of cryptogenic organizing pneumonia and HIV in a 45 year old man

Israr A. Sheikh, Naseem Saadia, Naveed Sheikh, Joan A. Culpepper-Morgan

Am J Case Rep 2012; 13:166-168

DOI: 10.12659/AJCR.883277

Available online:

Published: 2012-07-31


Background:    Cryptogenic organizing pneumonia (COP) is a small airways disease characterized by intraluminal polyps of myxoid connective tissue which follows a subclinical course and is associated with infectious as well as non infectious processes The concomitant occurrence of human immunodeficiency virus (HIV) infection and COP has rarely been reported. We describe a unique case in which COP was a presenting feature in a patient with newly diagnosed HIV Infection.
    Case Report:    A 45 year-old man with chronic active smoking presented to the ER with 15 months history of cough productive of minimal whitish sputum without frank or streaks of blood, low grade fever, anorexia and 4–6 lbs weight loss in past 6 months. He had three life time sexual partners. PPD status were unknown. He was extensively worked up as the Chest X ray showed cystic lesions all of which came back normal. Patient also received HIV test which was positive with CD 4 count of 546. He received bronchoscopy which revealed cryptogenic organising pneumonia. He was placed on steroids tapering course which helped in relieving the symptoms.
    Conclusions:    HIV infection with CD 4 count above 500 has seldom been reported having COP with this case being the second in literature but this entity should be kept in mind during management of these patients.

Keywords: HIV Infections, Cough, chronic cough, cryptogenic organizing pneumonia