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Medical Science Monitor Basic Research


Two difficulty diagnosis cases of severe veno-occlusive disease

Hisamitsu Miyaaki, Tatsuki Ichikawa, Naota Taura, Takuya Honda, Hidetaka Shibata, Taro Akashi, Shinobu Yamamichi, Shotaro Turuta, Akihiko Soyama, Masaaki Hidaka, Mitsuhisa Takatsuki, Sadayuki Okudaira, Susumu Eguchi, Osamu Nakashima, Masayoshi Kage, Kazuhiko Nakao

Am J Case Rep 2013; 14:86-90

DOI: 10.12659/AJCR.883864

Available online:

Published: 2013-03-29


Backgroud: The occurrence of Hepatic veno-occlusive disease (VOD) is rale liver disease. However, severe VOD is often lethal and one of the most common causes of death following stem cell transplantation (SCT).
Case Reports: Case 1 was a 30-year-old woman who was diagnosed as Budd-Chiari syndrome with liver failure. She was admitted to our department to undergo liver transplantation. Four days after admission, she underwent liver transplantation. Her liver explant showed VOD. Case 2 was a 74-year-old woman who was admitted to a community hospital for further examination. Her condition continued to deteriorate with liver failure, and she died 39 days after admission. Liver autopsy also showed VOD. Either of the patients had difficulty in diagnose as VOD. Neither of the patients had a history of SCT.
Conclusions: VOD should be considered as a cause of acute hepatic failure, even if the patient has no history of SCT.

Keywords: acute lliver failure, diagnostic difficulties, Hematopoietic stem cell transplant