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Simultaneous presentation of Kaposi sarcoma and HHV8-associated large B-cell lymphoma in the same lymph node: A rare diagnosis in an HIV-negative patient

Fabiola Fernandes, Catarina Eloy, Awa Carimo, Paula Pinto, Susannah Graves, Joana Simões, Carla Carrilho, José Manuel Lopes

Am J Case Rep 2013; 14:263-266

DOI: 10.12659/AJCR.883980

Available online:

Published: 2013-07-19

Background: KSHV/HHV-8 is associated with Kaposi’s sarcoma (KS) as well as with a few categories of lymphoproliferative diseases, mostly occurring in patients with HIV infection/AIDS. Although the association between lymphomas and Kaposi’s sarcoma has been described, the simultaneous presence of the 2 entities within the same organ is rare and mainly associated with HIV/ AIDS.
Case Report: We report a case of simultaneous occurrence of Kaposi‘s sarcoma and large B-cell lymphoma in the same lymph node in a 18-year-old African woman who was HIV-negative. We found concurrent infection with Kaposi’s sarcoma herpes virus (KSHV) and Epstein-Barr virus (EBV), confirmed by PCR amplification of DNA obtained from distinct tumor areas selected in the paraffin block.
Conclusions: The possibility of occurrence of 2 lesions with distinct features in the same organ may be unexpected for pathologists performing fine-needle aspiration cytology (FNAC) evaluation but must be considered, even in HIV-negative individuals, despite its rare occurrence, as was demonstrated by this case.

Keywords: HIV, Lymph Nodes, Sarcoma, Kaposi, Lymphoma, Large B-Cell, Diffuse