Scimago Lab
powered by Scopus
eISSN: 1941-5923
call: +1.631.629.4328
Mon-Fri 10 am - 2 pm EST


Medical Science Monitor Basic Research


Renal cell carcinoma in a setting of chronic lithium toxicity

Challenging differential diagnosis, Rare disease, Adverse events of drug therapy , Educational Purpose (only if useful for a systematic review or synthesis)

Ibrahim Zardawi, Santoshi Nagonkar, Purvish Patel

Australia Darwin, Australia

Am J Case Rep 2013; 14:300-303

DOI: 10.12659/AJCR.889398

Available online: 2013-08-07

Published: 2013-08-07


Background: Lithium salts are widely used in the treatment of affective disorders of the bipolar type. Lithium is a nephrotoxic substance which can cause both acute and chronic renal disease, including cyst formation. Cysts appear to predispose the kidney to renal cell carcinoma.
Case Report: A case of renal cell carcinoma in a background of acquired cystic disease due to chronic lithium toxicity is described.
Conclusions: Kidneys with multiple cysts are at risk of renal cell carcinoma. Although it is difficult to determine if long term Lithium use renal cell carcinoma, patients leads to the development of on long-term lithium therapy should undergo regular renal function and imaging tests.

Keywords: Carcinoma, Renal Cell, renal cysts, Anti-Inflammatory Agents, Non-Steroidal, Lithium Chloride, Kidney Neoplasms