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15 November 2013 : Case report  Lebanon

Congenital infantile fibrosarcoma: Association with bleeding diathesis

Unusual clinical course, Challenging differential diagnosis, Diagnostic / therapeutic accidents, Management of emergency care, Rare disease, Adverse events of drug therapy

Mayssaa SalmanBCDEF, Nabil J. KhouryAE, Ibarhim KhalifehAE, Hussein A. AbbasE, Marianne MajdalaniADE, Miguel AbboudE, Samar MuwakkitE, Hassan El SolhADE, Raya SaabACDEF

DOI: 10.12659/AJCR.889489

Am J Case Rep 2013; 14:481-485

Abstract

Background: Congenital infantile fibrosarcoma (CIF) is a soft-tissue tumor occurring during the first 2 years of life, most commonly in the extremities. CIF is frequently initially misdiagnosed as a vascular tumor, but its association with bleeding and coagulopathy has not been well characterized.
Case Reports:  We describe 2 infants with CIF presenting with bleeding and coagulopathy, requiring urgent intervention. Both patients did well; one underwent partial resection followed by chemotherapy, and the other received 2 cycles of chemotherapy followed by gross total resection. We also provide a review of all reported cases of coagulopathy in the setting of CIF in the English literature, uncovering an association that seems to be more prevalent in patients diagnosed in the neonatal period, with associated anemia and thrombocytopenia, and a significant mortality rate.
Conclusions: CIF needs to be considered in the differential diagnosis of vascular congenital tumors, especially when there is evidence of bleeding, anemia, or thrombocytopenia.

Keywords: Congenital infantile fibrosarcoma, bleeding, vascular tumor

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923