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Medical Science Monitor Basic Research


A case with unusual stroke and fulminant outcome in a Hispanic male

Mistake in diagnosis, Rare disease

Sarmad Said, Chad J. Cooper, Farhanaz Chowdhury, Angelica Nunez, Raphael Quansah, Harry E. Davis II

USA Department of Internal Medicine, Texas Tech University Health Science Center, El Paso, USA

Am J Case Rep 2013; 14:424-429

DOI: 10.12659/AJCR.889590

Available online: 2013-10-21

Published: 2013-10-21


Background: Moyamoya disease (MMD) was first described in 1957 as “hypoplasia of the bilateral internal carotid arteries.” The characteristic appearance of the associated network of abnormally dilated collateral vessels on angiography was later likened to “something hazy, like a puff of cigarette smoke,” which, in Japanese, is Moyamoya. This paper describes the fulminant course of the disease in a Hispanic male involving the corpus callosum.
Case Report: A 42-year-old Hispanic male with progressive aphasia, slow mentation, and sudden onset of sensorimotor symptoms with gait disturbance was found to have multiple intracranial supratentorial infarcts of variable stages of evolution involving, but not limited to, the anterior corpus callosum, followed by rapid development of further infarcts. Angiography demonstrated right ACA occlusion, left supraclinoid ICA occlusion with a Moyamoya pattern of collateralization, and diffuse arteriopathy. A fulminant course ensued and the patient did not survive the acute phase of ischemic disease.
Conclusions: Moyamoya disease may rarely present in North American Hispanic males, with advanced atypical clinical and imaging features involving the anterior corpus callosum and having a fulminant course.

Keywords: Stroke, moyamoya disease, Corpus Callosum, cerebral infarction