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Cavitating lung lesion as a manifestation of inflammatory tumor (pseudotumor) of the lung: A case report and literature review

Unusual clinical course, Challenging differential diagnosis, Diagnostic / therapeutic accidents, Rare disease

Stylianos A. Michaelides, Elisabeth Passalidou, George D. Bablekos, Evlambia Aza, George Goulas, Maria Chorti, Irene N. Nicolaou, Achilleas G. Lioulias

Department of First Thoracic Medicine, “Sismanogleion” General Hospital, Maroussi, Attiki, Athens , Greece

Am J Case Rep 2014; 15:258-265

DOI: 10.12659/AJCR.890466

Available online:

Published: 2014-06-17

Background: Inflammatory pseudotumor of the lung involves a benign, non-neoplastic lung lesion of unknown etiology.
Case Report: We present a case of a 60-year-old female smoker who had been under intermittent immunosuppressive medication for discoid lupus, who was admitted to hospital with fever of 39.5°C of 10-day duration, not responding to an oral cephalosporin. Chest CT examination showed a cavitating opacity in the upper zone of the left lung. It was not feasible to establish a diagnosis based on clinical and laboratory testing nor based on CT scanning and bronchoscopy. Thus, the patient underwent left thoracotomy and sphenoid resection of the lesion, which was sent for biopsy. The histopathologic features aided by immunohistochemical staining proved the lesion to be an inflammatory pseudotumor of the lung.
Conclusions: The case is reported because of the extremely rare radiologic presentation of the development of a lung pseudotumor emerging as a cavitated lesion, which relapsed during the follow-up period while the patient was still under immunosuppressive medication.

Keywords: Plasma Cell Granuloma, Pulmonary - immunology, Plasma Cell Granuloma, Pulmonary - radiography, Plasma Cell Granuloma, Pulmonary - surgery, Plasma Cell Granuloma, Pulmonary - therapy