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Burkitt Lymphoma with Initial Clinical Presentation due to Infiltration of the Central Nervous System and Eye Orbits

Unusual clinical course, Challenging differential diagnosis, Educational Purpose (only if useful for a systematic review or synthesis)

Gustavo Bittencourt Camilo, Dequitier Carvalho Machado, Celso Estevão de Oliveira, Letícia da Silva Lacerda, Romulo Varella de Oliveira, Monique de França Silva, Agnaldo José Lopes

(Postgraduate Programe in Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro, Brazil)

Am J Case Rep 2014; 15:404-410

DOI: 10.12659/AJCR.891224

Published: 2014-09-22

Background: Burkitt lymphoma rarely affects the central nervous system and ocular region. Under these conditions, computed tomography and (particularly) magnetic resonance imaging of the skull increase the diagnostic accuracy, as they objectively show the topography of lesions and the effect of neoplasia on structures.
Case Report: We report here the case of a 17-year-old male whose initial clinical manifestations were related to neurological impairment and to the ocular musculature and ocular innervation. The diagnosis of Burkitt lymphoma with leukemization and infiltration of the central nervous system was confirmed.
Conclusions: In this case, it is important to recognize that the neuroimaging findings were fundamentally important in indicating the initial form of the disease and in directing the appropriate clinical management.

Keywords: Burkitt Lymphoma - diagnosis, Brain Neoplasms - diagnosis, Biopsy, Adolescent, Central Nervous System - radiography, Diagnosis, Differential, Humans, Magnetic Resonance Imaging, Male, Orbital Neoplasms - diagnosis, Tomography, X-Ray Computed