Scimago Lab
powered by Scopus
eISSN: 1941-5923
call: +1.631.629.4328
Mon-Fri 10 am - 2 pm EST


Medical Science Monitor Basic Research


Microcystic/Reticular Schwannoma: Morphological Features Causing Diagnostic Dilemma on Fine-needle Aspiration Cytology

Unusual clinical course, Challenging differential diagnosis, Diagnostic / therapeutic accidents

Shunyou Gong, Said Hafez-Khayyata, Wei Xin

USA Department of Pathology, University Hospitals of Cleveland and Case Western Reserve University School of Medicine, Cleveland, USA

Am J Case Rep 2014; 15:538-542

DOI: 10.12659/AJCR.892196

Available online: 2014-12-04

Published: 2014-12-04


Background: Schwannoma is a common, benign, peripheral nerve sheath tumor. Fine-needle aspiration (FNA) has been very useful for diagnosing classic Schwannoma. Recently, a new morphological variant, the so-called microcystic/reticular Schwannoma, has been recognized. Although histological features of microcystic/reticular Schwannoma have been described, there are no available reports on its FNA cytological appearance.
Case Report: A 28-year-old male presented with right arm and finger tingling and numbness. Physical examination found a right lower neck mass. He underwent FNA, followed by needle core biopsy. A diagnosis of microcystic/reticular schwannoma was made. In this case report, we focused on the FNA diagnostic features, thoroughly searched the literature, and discussed relevant information for differential diagnosis.
Conclusions: Unlike classic Schwannoma, microcystic/reticular variant has unique cytological features which can mimic those of several morphologically similar mass lesions, making the FNA interpretation more challenging. Cytopathologists should be aware of this new variant of Schwannoma when evaluating FNA cytology of mass lesions showing low-grade, paucicellular, and myxoid features.

Keywords: Biopsy, Fine-Needle - methods, Adult, Cytodiagnosis, Diagnosis, Differential, Neurilemmoma - diagnosis, Peripheral Nervous System Neoplasms - diagnosis