Logo American Journal of Case Reports

Call: 1.631.629.4328
Mon-Fri 10 am - 2 pm EST

Contact Us

Logo American Journal of Case Reports Logo American Journal of Case Reports Logo American Journal of Case Reports

14 May 2015 : Case report  USA

Pulmonary Metastasis in a Patient with Simultaneous Bladder Cancer and Relapsing Granulomatosis with Polyangiitis

Unusual clinical course, Challenging differential diagnosis

Mauricio DanckersABCDEF, Fang ZhouDEF, Diana NimehD, H. Michael BelmontDEF, David J. SteigerABCDEFG

DOI: 10.12659/AJCR.893406

Am J Case Rep 2015; 16:287-291

Abstract

BACKGROUND: Granulomatosis with polyangiitis (GPA) relapse can complicate the differential diagnosis of pulmonary lesions.

CASE REPORT: A 70-year-old male smoker with GPA and emphysema presented with dyspnea, dry cough, and a right upper lobe pulmonary ground-glass opacity that persisted despite antibiotics. A trans-bronchial biopsy did not reveal active vasculitis, malignancy, or infection. He was treated for presumed GPA relapse based on pulmonary manifestations, renal failure, and elevated PR3-ANCA. Later, hematuria led to the cystoscopic discovery of a bladder wall lesion, which was diagnosed as micropapillary urothelial carcinoma not involving the muscularis propria. The patient developed an increasing pulmonary infiltrate with a new solid component, satellite lesions, and regional lymphadenopathy. A right upper lobe wedge resection showed metastatic urothelial carcinoma.

CONCLUSIONS: The simultaneous presentation of a pulmonary lesion and GPA relapse is a diagnostic challenge. The differential diagnosis should include the rare possibility of metastatic urothelial carcinoma, regardless of how the lesion appears radiographically.

Keywords: Bronchoscopy, Biopsy, Aged, 80 and over, Carcinoma, Transitional Cell - secondary, Cystoscopy, Diagnosis, Differential, Granulomatosis with Polyangiitis - diagnosis, Lung Neoplasms - secondary, Tomography, X-Ray Computed, Urinary Bladder Neoplasms - pathology

0 Comments

SARS-CoV-2/COVID-19

13 May 2022 : Case report  Japan

A case of exacerbation of haloperidol-induced rhabdomyolysis following the onset of COVID-19

Am J Case Rep In Press; DOI: 10.12659/AJCR.936589  

13 May 2022 : Case report  USA

Acute Disseminated Encephalomyelitis After SARS-CoV-2 Vaccination

Am J Case Rep In Press; DOI: 10.12659/AJCR.936574  

20 April 2022 : Case report  Indonesia

Progressive Worsening of Neurological Manifestations in HIV-Associated Opportunistic Central Nervous System...

Am J Case Rep In Press; DOI: 10.12659/AJCR.936257  

20 April 2022 : Case report  USA

A 62-Year-Old Man Presenting with Bilateral Tremor of the Upper Limb After a Diagnosis of COVID-19 with Con...

Am J Case Rep In Press; DOI: 10.12659/AJCR.934955  

In Press

16 May 2022 : Case report  Saudi Arabia

Primary Central Nervous System Burkitt Lymphoma, Presenting with Long-Term Fluctuating Level of Consciousne...

Am J Case Rep In Press; DOI: 10.12659/AJCR.936401  

16 May 2022 : Case report  USA

Long-Term Efficacy of Dupilumab in Alopecia Areata

Am J Case Rep In Press; DOI: 10.12659/AJCR.936488  

16 May 2022 : Case report  USA

Stellate Hypopigmentation in a Pediatric Patient After Treatment with Intralesionally-Injected Corticosteroid

Am J Case Rep In Press; DOI: 10.12659/AJCR.935898  

13 May 2022 : Case report  Japan

A case of exacerbation of haloperidol-induced rhabdomyolysis following the onset of COVID-19

Am J Case Rep In Press; DOI: 10.12659/AJCR.936589  

Most Viewed Current Articles

23 Feb 2022 : Case report  USA

Penile Necrosis Associated with Local Intravenous Injection of Cocaine

DOI :10.12659/AJCR.935250

Am J Case Rep 2022; 23:e935250

17 Feb 2022 : Case report  Oman

Myocarditis, Pulmonary Hemorrhage, and Extensive Myositis with Rhabdomyolysis 12 Days After First Dose of P...

DOI :10.12659/AJCR.934399

Am J Case Rep 2022; 23:e934399

06 Dec 2021 : Case report  Brazil

Lipedema Can Be Treated Non-Surgically: A Report of 5 Cases

DOI :10.12659/AJCR.934406

Am J Case Rep 2021; 22:e934406

19 Feb 2022 : Case report  USA

A Rare Case of Coronavirus Disease 2019 Vaccine-Associated Cerebral Venous Sinus Thrombosis Treated with Me...

DOI :10.12659/AJCR.935355

Am J Case Rep 2022; 23:e935355

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923