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Medical Science Monitor Basic Research


Wait!!! No Steroids for this Asthma…

Unusual clinical course, Unusual or unexpected effect of treatment, Unexpected drug reaction , Educational Purpose (only if useful for a systematic review or synthesis)

Abdelhamid Alsharif, Amik Sodhi, Luis C. Murillo, Arthur S. Headley, Dipen Kadaria

USA Division of Pulmonary, Critical Care, and Sleep Medicine, University of Tennessee Health Science Center, College of Medicine at Memphis, Memphis, TN, USA

Am J Case Rep 2015; 16:398-400

DOI: 10.12659/AJCR.893729

Available online: 2015-06-26

Published: 2015-06-26


BACKGROUND: Strongyloides stercoralis (SS) is a parasite seen in certain parts of the USA and in people from other endemic areas. In these patients steroids might precipitate or exacerbate asthma. Apart from worsening of asthma, serious complications like hyperinfection syndrome and even death can occur in these patients if treated with steroids. Treatment is either ivermectin or albendazole based on severity of the disease. Clinicians have to be very careful when prescribing steroids in patients presenting with an exacerbation of asthma from areas endemic for Strongyloides stercoralis.
CASE REPORT: A young woman with history of asthma presented with complaints of nausea, vomiting, abdominal pain, wheezing, and dry cough. Physical examination revealed diffuse expiratory wheezing and mild diffuse abdominal pain without rebound or guarding. Laboratory results showed leukocytosis with eosinophilia. Stool studies showed Strongyloides stercoralis. Imaging revealed ground-glass opacities in the right upper and lower lobe along with an infiltrate in the lingular lobe on the left side. Bronchoscopy showed Strongyloides stercoralis. The patient was diagnosed with hyperinfection syndrome due to Strongyloides stercoralis most probably exacerbated by prednisone given for her asthma. Steroids were then discontinued and the patient was started on ivermectin. The patient improved with treatment. Repeat stool examination was negative for Strongyloides stercoralis.
CONCLUSIONS: Clinicians have to be very careful when prescribing steroids in patients presenting with an exacerbation of asthma who are from areas endemic for Strongyloides stercoralis and should test for it (preferably with serology test) before starting treatment.

Keywords: Animals, Adult, Antiparasitic Agents - therapeutic use, Asthma - therapy, Bronchoscopy, Diagnosis, Differential, Glucocorticoids - contraindications, Ivermectin - therapeutic use, Strongyloides stercoralis - isolation & purification, Strongyloidiasis - therapy, Tomography, X-Ray Computed