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Medical Science Monitor Basic Research


Gastric Bezoar Treatment by Endoscopic Fragmentation in Combination with Pepsi-Cola® Administration

Unusual setting of medical care, Unexpected drug reaction , Rare disease, Educational Purpose (only if useful for a systematic review or synthesis)

Masaya Iwamuro, Naoko Yunoki, Jun Tomoda, Kazuhiro Nakamura, Hiroyuki Okada, Kazuhide Yamamoto

Japan Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan

Am J Case Rep 2015; 16:445-448

DOI: 10.12659/AJCR.893786

Available online:

Published: 2015-07-10


Background: Although bezoar dissolution by Coca-Cola® has been described in case reports and case series, to the best of our knowledge, the usefulness of other cola products such as Pepsi-Cola® has never been reported in the English literature.
Case Report: An 86-year-old Taiwanese man was diagnosed with a gastric bezoar. Endoscopic fragmentation with a polypectomy snare was attempted twice but failed to remove the bezoar. Subsequently, 500 mL of Pepsi NEX Zero® was administered daily for 4 days via nasogastric tube. The bezoar was softened and successfully fragmented by the polypectomy snare and needle-knife devices on the third attempt.
Conclusions: This report presents the first case of a gastric bezoar successfully treated by endoscopic fragmentation in combination with Pepsi-Cola® administration, suggesting the possible utility of cola beverages in bezoar treatment, regardless of product brands.

Keywords: Bezoars - therapy, Aged, 80 and over, Carbonated Beverages, Gastroscopy - methods, Stomach