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Medical Science Monitor Basic Research


Primary Peritoneal Mesothelioma Resulting in Small Bowel Obstruction: A Case Report and Review of Literature

Challenging differential diagnosis, Rare disease

S. Christopher N. Frontario, Andrew Loveitt, Anna Goldenberg-Sandau, Jun Liu, Darshan Roy, Larry W. Cohen

USA Department of Surgery, Rowan University School of Osteopathic Medicine, Stratford, NJ, USA

Am J Case Rep 2015; 16:496-500

DOI: 10.12659/AJCR.894180

Available online: 2015-07-28

Published: 2015-07-28


BACKGROUND: Peritoneal mesothelioma is a rare malignancy that affects the serosal surfaces of the peritoneum. The peritoneum is the second most common site of mesothelium affected following the pleura. The aggressive nature and vague presentation pose many obstacles in not only diagnosis but also the treatment of patients with this disease.
CASE REPORT: We present a case of a 76-year-old woman who presented with small bowel obstruction secondary to carcinomatosis secondary to primary peritoneal mesothelioma. The patient had multiple risk factors with asbestos exposure and prior therapeutic radiation.
CONCLUSIONS: We discuss the highly varied and elusive presentation of peritoneal mesothelioma. Cumulative asbestos exposure, either directly or indirectly, remains the leading cause of mesothelioma. However, there are other non-asbestos etiologies. Small bowel obstruction often is a late-presenting symptom of widespread tumor burden. A concise review of the current diagnostic and surgical treatment of primary peritoneal mesothelioma demonstrates that early diagnosis and implementation remains vital.

Keywords: Intestinal Obstruction - therapy, Intestine, Small, Lung Neoplasms - therapy, Mesothelioma - therapy, Peritoneal Neoplasms - therapy