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A Case of BK Nephropathy without Detectable Viremia or Viruria

Unusual clinical course, Challenging differential diagnosis, Educational Purpose (only if useful for a systematic review or synthesis)

Mahmoud Kamel, Manish Kadian, Maria Nieva Salazar, Prince Mohan, Sally Self, Titte Srinivas, Maria Aurora Posadas Salas

Division of Nephrology and Hypertension, Department of Medicine, Medical University of South Carolina, Charleston, SC, USA

Am J Case Rep 2015; 16:532-535

DOI: 10.12659/AJCR.894314

Available online:

Published: 2015-08-13

BACKGROUND: BK nephropathy is an evolving challenge among kidney transplant recipients. Diagnosis of BK nephropathy depends on the presence of BK viral inclusions on renal biopsy. Most cases of BK nephropathy are preceded by BK viremia or viruria.
CASE REPORT: We report a case of BK nephropathy found on protocol renal transplant biopsy without associated BK viremia or viruria.
CONCLUSIONS: BK nephropathy may occur even in the absence of BK viremia or viruria. Protocol biopsy is a useful tool to detect these cases.

Keywords: BK Virus, Kidney Diseases - virology, Polyomavirus Infections - therapy, Tumor Virus Infections - therapy